Functional Nanofiber-based Devices for Wound Healing Applications

在过去的几十年里，许多研究都集中在利用材料来开发设备，通过制造纳米纤维的应用，如生物医学纳米技术，导致伤口愈合领域的发展。在所使用的各种材料中，包括聚吡咯、聚苯胺（PANi）、聚（己内酯）（PCL）、聚（L-丙交酯）（PLA）和石墨烯基复合材料的聚合物是少数几种已经被证明具有导电性以用作装置的电极的材料，尽管它们的导电性低。此外，据观察，压电/摩擦电纤维（例如PVDF，PLLA聚合物）收集能量，可用作纳米发电机或动态压力传感器[1]。目前，重要的研究旨在开发基于导电纤维和压电/摩擦电纤维的组合的新型治疗方法，用于更多种类的受伤组织，如皮肤。它们的形态和性能可以通过聚合物溶液性质（例如粘度、复合比和电导率）和静电纺丝参数（例如电压、流速和收集器距离）来调节，以增强器件性能。导电纳米纤维已经显示出显著的生物活性，因为它们的支架具有电模拟，显示出促进细胞接种和促进细胞增殖和分化[2]。该项目将处理开发先进设备的工程方面，通过使用功能性电纺纳米纤维（导电和压电/摩擦电）用于伤口愈合或监测一些重要的健康参数等应用。这项研究将解决的问题是如何提高导电纳米纤维的导电性，以用作完全基于压电摩擦电纤维的设备的电极，以及它们对伤口愈合的影响。

Over the past decades much research has focused on utilizing materials to develop devices by fabricating nanofibers for applications, such as biomedical nanotechnology, leading to the development of the field of wound healing. Among the various materials utilized, polymers including polypyrrole, polyaniline (PANi), poly(caprolactone) (PCL), poly(L-lactide) (PLA) and graphene based composites are among the few that have been demonstrated conductivity to be used as electrodes for devices, despite their low conductivity. Moreover, it is observed that piezo/triboelectric fibers (e.g. PVDF, PLLA polymers) harvest energy and can be used as nano-generators or dynamic pressure sensors [1]. Currently, significant research aims to develop novel treatments based on a combination of conductive and piezo/triboelectric fibers for more kinds of injured tissues such as skin. Their morphology and performance can be tuned with the polymer solution properties (e.g. viscosity, composite ratio and conductivity) and electrospinning parameters (e.g. Voltage, flow rate and collector distance) in order to enhance the device performance. Conductive nanofibers have demonstrated significant biological activity since their scaffolds with electrical simulation showed facilitating cell seeding and promoting cell proliferation and differentiation [2]. This project will deal with engineering aspects of developing advanced devices by using functional electrospun nanofibers (conductive and piezo/triboelectric) for applications such as wound healing or monitor some vital health parameters. The question that this research will address is how the conductivity of conductive nanofibers can be advanced to be used as electrodes for a device full-based on piezo-triboelectric fibers and what are their effect on wound healing.