2006 Muscle: Excitation/Contraction Coupling Gordan Conference

描述（由申请人提供）：本提案旨在支持唯一一次致力于骨骼肌兴奋收缩偶联和改变该过程的疾病的国际会议。肌肉：兴奋收缩戈登会议将于2006年6月4日至9日在新罕布什尔州新伦敦的科尔比索耶学院举行，将有大约150名与会者。该会议始于1970年，自那时以来每三年举行一次会议。2006年，该会议将有代表8个不同国家的31名发言者。由于公开讨论是一个成功的戈登会议的重要组成部分，我们已经允许相当多的时间进行讨论，并将有18个讨论领导人。主题包括E-C偶联蛋白的结构和相互作用，E-C偶联的调节和调控，E-C偶联蛋白在肌肉疾病中的作用，以及激发转录偶联。2006年会议的新内容将是对肌肉损伤和修复的讨论，特别强调细胞内Ca 2+浓度变化的作用。从历史上看，激发-收缩耦合戈登会议和离子通道戈登会议都是从早期的戈登会议中产生的，该会议不仅解决了与肌肉有关的问题，而且还解决了更普遍的离子通道问题。显然，这两个领域相互重叠，彼此有很大的贡献。因此，组织2006年EC偶联会议的一个重要目标是将致力于非肌肉系统（如免疫和神经系统）中离子通道和钙信号传导的主要研究人员纳入其中。这已经变得特别相关，因为最近的工作已经证明肌肉具有类似于非兴奋细胞的钙再填充途径。

DESCRIPTION (provided by applicant): This proposal is for support of the only international meeting dedicated to skeletal muscle excitation contraction coupling and the diseases that alter this process. The Muscle: Excitation Contraction Gordon conference will meet June 4-9, 2006 at Colby-Sawyer College in New London, New Hampshire and will have approximately 150 participants. This conference began in 1970 and has met every 3 years since that time. In 2006, this conference will have 31 speakers representing 8 different counties. Since open discussion is a crucial part of a successful Gordon conference, we have allowed considerable time for discussion and will have 18 discussion leaders. Topics include structure and interactions of E-C coupling proteins, modulation and regulation of E-C coupling, the role of E-C coupling proteins in muscle disease, and excitation transcription coupling. New to the 2006 conference will be a discussion of muscle damage and repair with a particular emphasis on the role in alterations in intracellular Ca2+ concentrations. Historically, both the Excitation-Contraction Coupling Gordon Conference and the Ion Channel Gordon Conference emerged from an earlier Gordon Conference which addressed issues relating not only to muscle in particular but also to ion channels more generally. Clearly, the two fields overlap and have much to contribute to one another. Thus, an important goal for organizing the 2006 EC coupling conference was to incorporate leading investigators working on ion channels and calcium signaling in non-muscle systems such as the immune and nervous systems. This has become particularly relevant since recent work has demonstrated the muscle possesses calcium refilling pathways similar to those of non-excitable cells.