14th International HLA & Immunogenetics Workship (HIWS)

第14届国际人类白细胞抗原和免疫遗传学研讨会将于2005年11月29日至12月3日在澳大利亚墨尔本大学举行。之前的13个讲习班都是在北半球举行的。研讨会聚集了研究人类白细胞抗原和免疫遗传学的国际顶尖科学家，讨论合作研究项目的结果。讲习班旨在通过多中心国际合作解决具体的科学问题，从而开发公共可用的研究资源。研讨会活动包括：1.控制实体器官和造血干细胞移植结果的遗传多态的特征；2.对传染病、癌症和自身免疫性疾病的免疫反应的遗传控制；3.建立免疫反应基因的遗传数据库，包括人类白细胞抗原等位基因和单倍型；4.开发用于分析遗传数据的生物信息学和统计学工具；5.移植中的次要抗原的定义；6.与人类白细胞抗原分子结合的多肽的特征；7.基因检测方案和MHC基因命名的标准化；8.创建全球使用的多样性细胞小组；9.人类免疫反应基因变异的人类学定义；10.用于疾病基因定位的高密度SNP数据库的开发，11.KIR基因多样性的定义，12.移植中的虚拟匹配技术。第14届IHIWS在每个研究项目所涉及的国际合作范围和 这项活动在人类白细胞抗原和免疫遗传学研究社区内促进了非凡的科学网络。这允许将使用标准化协议收集的数据汇集在一起，从而赋予研究项目更大的权力。标准化试剂在参与者之间共享，化验在每个参与的实验室进行质量控制。研讨会将是对技术进步进行基准评估的主要论坛，促进技术跨越国界的交流，并通过行业利用研讨会的机会来实施新的进步。研讨会的数据将存档在一个由美国国立卫生研究院支持的可公开访问的数据库中。研讨会报告和摘要将在同行评议的文献和研讨会上发表 书。将邀请由6名主要研究人员组成的核心成员作为演讲者，并支持来自发展中国家的10名科学家作为参与者或演讲者。还将向博士后科学家提供四项奖学金，以优异成绩为基础。该计划将介绍和讨论研讨会项目。研讨会将向所有感兴趣的学生、实习生、科学家和临床医生开放。将在会议上进行的科学交流将推动未来5年免疫遗传学的研究并保持国际合作。

The 14th International HLA and Immunogenetics Workshop will be held at The University of Melbourne, Australia, between November 29-December 3, 2005. All 13 previous workshops have been held in the northern hemisphere. The Workshop brings together leading international scientists studying HLA and immunogenetics to discuss the findings of collaborative research projects. The Workshop aims to address specific scientific questions through multicenter international collaboration that leads to development of publically available research resources. The Workshop actvities include: 1. Characterization of genetic polymorphisms that control the outcome of solid organ and hemopoietic stem cell transplantation, 2. Genetic control of immune responses to infectious disease, cancer and autoimmune disorders, 3. Creation of genetic databases of immune response genes including HLA alleles and haplotypes, 4. Development of bioinformatic and statistical tools for analysis of genetic data, 5. Definition of minor antigens in transplantation, 6. characterization of peptides bound to HLA molecules, 7. Standardization of gene testing protocols and MHC gene nomenclature, 8. creation of diversity cell panels used worldwide, 9. Anthropological definition of human variation in immune response genes, 10. Development of high density SNP databases for disease gene mapping, 11. definition of KIR gene diversity, 12. Virtual matching techniques in transplantation. The 14th IHIWS is unique in the extent of international collaboration involved in each of the research projects and the remarkable scientific networking this activity promotes within the HLA and immunogenetics research community. This allows pooling of data that has been collected using standardised protocols imparting much greater power to research projects. Standardised reagents are shared between participants and assays undergo quality control in each of the participating laboratories. The workshop will be a major forum for benchmarking advances in technology, facilitating their exchange across international boundaries and implementation of new advances through industry uptake of Workshop opportunities. The data from the workshop will be archived in a publicly accessible database supported by the US National Institutes of Health. Workshop reports and abstracts will be published in the peer-reviewed literature and in a Workshop book. A core of 6 leading investigators will be invited as speakers and 10 scientists from developing nations will be supported as participants or speakers. Four Bursaries will also be offered to postdoctoral scientists on a merit basis. The program will present and discuss workshop projects. The Workshop will be open to all interested students, trainees, scientists and clinicans. The scientific exchange that will take place at the meeting will drive research and maintain international collaboration in immunogenetics for the next 5 years.