PEMPHIGUS 2005-PROGRESS AND FUTURE DIRECTIONS

描述（由申请人提供）：天疱疮是一种严重的皮肤起泡疾病。它是一种模型自身抗体介导的疾病，由自身抗体对抗角质形成细胞粘附分子桥蛋白1和3引起。天疱疮的发病机制和开发新的治疗方法正在取得快速进展。关于这种疾病的第一次全国会议四年前在国立卫生研究院校园举行，非常成功。我们现在提议召开一个后续会议——“天疱疮2005 -进展和未来方向”。它将汇集基础科学家和临床研究人员，研究人类自身抗体介导的疾病的机制和新的治疗方法，特别是天疱疮。我们对天疱疮的原因和治疗的理解的最新发展将进行审查。我们的目标是找出最有效地促进我们进一步了解天疱疮病因和治疗方法的研究机会，并在感兴趣的研究人员之间就如何达到这些目标进行交叉杂交。会议将围绕两个主要主题组织，每个主题持续一天：1)我们对天疱疮发病机制的理解的进展，以及2)这种疾病的治疗进展。计划举办两个讲习班，以便在该领域的工作人员中就天疱疮的诊断标准和用于评估这种疾病的程度、活动、严重程度和治疗反应的参数达成共识。对于不能在会议上口头陈述的进展，将有一个海报环节。这次会议是由两个主要的国家非专业组织赞助的——一个对天疱疮感兴趣（国际天疱疮基金会），另一个对自身免疫性疾病更感兴趣（美国自身免疫性相关疾病协会）。我们预计它将吸引100-150名科学家和临床医生致力于研究和治疗天疱疮。

DESCRIPTION (provided by applicant): Pemphigus is a serious blistering disease of the skin. It is a model auto-antibody mediated disease, caused by auto-antibodies against the keratinocyte adhesion molecules desmoglein 1 and 3. Rapid advances are being made understanding the pathogenesis of pemphigus and developing novel approaches to it. The first national conference on this disease was held on the NIH campus 4 years ago and was very successful. We now propose a follow-up conference-- "Pemphigus 2005 - Progress and Future Directions". It will bring together basic scientists and clinical investigators working on the mechanisms of, and novel therapeutic approaches to, human auto-antibody mediated diseases in general and pemphigus specifically. Up-to-date developments in our understanding of the causes and the treatment of pemphigus will be reviewed. The goal will be to identify are as of research opportunity that will most effectively promote our further understanding of the causes and the treatments of pemphigus, and to cross-hybridize ideas on how to reach these goals among interested researchers. The conference will be organized around two major themes, each of one day's duration: 1) Advances in our understanding of the pathogenesis of pemphigus, and 2) advances in the treatment of this disease. Two workshops are planned to establish consensus among workers in the field on the diagnostic criteria for pemphigus and on the parameters used to evaluate the extent, activity, severity and response to therapy of this disease. There will be a poster session for advances that cannot be presented orally at the meeting. The conference is sponsored by two leading national lay organizations- one interested in pemphigus (International Pemphigus Foundation) the other more generally interested in autoimmune diseases (American Autoimmune Related Diseases Association. We expect it will attract 100-150 scientists and clinicians dedicated to investigate and treating pemphigus.