6th International Conf. on Cryptococcus & Cryptococcosis

描述（由申请人提供）：本提案的目的是请求部分支持将于2005年6月24日至28日在马萨诸塞州波士顿的波士顿万豪长码头酒店举行的“第六届隐球菌和隐球菌病国际会议”。本次会议的重点是新型隐球菌在发达国家和发展中国家的公共卫生影响，以及基础和应用研究如何有助于诊断，治疗和预防这些真菌引起的疾病。这个重要的国际会议每三年举行一次，通常吸引来自30多个国家的250多名科学家。第一次会议于1989年11月在以色列的耶路撒冷举行。随后在意大利米兰、法国巴黎、英国伦敦和澳大利亚阿德莱德举行了会议。这是该会议首次在美国举行。过去的会议使来自不同科学背景的科学家能够建立密切的互动关系，交流思想、专门知识和新技术。这种跨学科的合作促进了公开对话，预计第六届隐球菌和隐球菌病国际会议将继续这一传统。该提案要求为会议的行政管理和20名研究生、博士后研究员和青年研究员出席会议提供支助。会议的具体目的是：1）汇集来自学术界、政府和工业界的研究人员，研究C。新生菌和隐球菌病; 2）对隐球菌病多变的临床表现的最新治疗技术达成共识，并评估治疗和预防隐球菌病的新策略，包括疫苗的作用; 3）评估目前对隐球菌病的分子机制的研究。新形虫能够入侵和逃避宿主免疫系统; 4）讨论C.新形线虫基因组的研究以及新的分子工具的出现，将有助于在基因调控、分子发病机制、治疗和疫苗开发等方面取得进展;新型和隐球菌病，并建议新的和未来的研究计划，并优先考虑这些。

DESCRIPTION (provided by applicant): The purpose of this proposal is to request partial support for "The 6th International Conference on Cryptococcus and Cryptococcosis" which will be held June 24-28, 2005 at the Boston Marriott Long Wharf Hotel in Boston, Massachusetts. The emphasis of this Conference is the public health impact of Cryptococcus neoformans in both developed and developing countries, and how basic and applied research are contributing to the diagnosis, treatment, and prevention of diseases caused by these fungi. This major international conference is held every three years and typically attracts over 250 scientists from over 30 countries. The first conference in the series was held in Jerusalem, Israel in November, 1989. Subsequent conferences have been held in Milan, Italy; Paris, France; London, England; and Adelaide, Australia. This is the first time this conference is being held in the United States. The conferences in the past have allowed for the establishment of close interactions among scientists from different scientific backgrounds for an exchange of ideas, expertise, and new technologies. Such interdisciplinary collaborations have fostered open dialogues and it is expected that the 6th International Conference on Cryptococcus and Cryptococcosis will continue in this tradition. This proposal requests support for administration of the meeting and for 20 graduate students, postdoctoral fellows and young investigators to attend the conference. The Specific Aims of the meeting are: 1) To bring together investigators from academia, governments and industry who study C. neoformans and Cryptococcosis; 2) To develop a consensus on the state of the art for treating the protean manifestations of Cryptococcosis and to evaluate new strategies to treat and prevent disease, including the role of vaccines; 3) To assess the current studies on the molecular mechanisms by which C. neoformans is able to invade and evade the host immune system; 4) To discuss how the recent sequencing of the C. neoformans genome, as well as the availability of new molecular tools, can facilitate advances in understanding gene regulation, molecular pathogenesis, therapy, and vaccine development; 5) To develop new research agenda for the study of C. neoformans and Cryptococcosis and to recommend new and future research initiatives and prioritize these.