Molecular Pathology of Lung Cancer

描述（由申请人提供）：本提案旨在于2005年2月23日至27日在加州圣地亚哥组织一次题为“肺癌分子发病机制转化为临床的机会”的科学会议。本次AACR特别会议汇集了肺癌基础、转化和临床研究领域的领先科学家和医生。肺癌是美国和世界上许多国家男性和女性最大的癌症杀手。本次会议的重点是关于肺癌各个方面的许多新的重要转化进展，这些进展有望为阻止这一致命疾病提供一种基本方法。这些包括：了解其分子发病机制；遗传流行病学;尼古丁成瘾的遗传学及对戒烟治疗的反应包括分子检测在内的早期检测策略；化学预防;肿瘤和血液的分子图谱（mRNA，蛋白质组学和DMA）提供肺癌临床行为的详细信息和对治疗反应的预测；诊断和评价治疗反应的新影像学方法以及新的靶向疗法的发展。此外，动物尤其是小鼠肺癌模型的建立为系统地认识和治疗肺癌提供了重要的新途径。同意参加的演讲者是这些领域的一些领先的跨学科研究人员，他们积极寻求将他们的发现转化为临床和实验室。

DESCRIPTION (provided by applicant): The aim of this proposal is to organize a scientific meeting entitled "Opportunities for Translation of the Molecular Pathogenesis of Lung Cancer to the Clinic", in San Diego, California from February 23 - 27, 2005. This AACR Special Conference brings together scientists and physicians that are leaders in the basic, translational, and clinical fields of lung cancer research. Lung cancer is the biggest cancer killer of men and women in the USA and in many countries around the world. This conference focuses on the many new important translational advances dealing with all aspects of lung cancer that promise a rationale approach to stopping this deadly disease. These include: understanding its molecular pathogenesis; genetic epidemiology; genetics of nicotine addiction and response to anti-smoking therapy; strategies for early detection including molecular detection; chemoprevention; molecular profiling (mRNA, proteomic, and DMA) of tumors and blood to provide detailed information on lung cancer clinical behavior and prediction of response to therapy; new imaging approaches for diagnosis and evaluation of therapeutic response; and the development of new targeted therapies. In addition, the development of animal, particularly mouse models of lung cancer provide an important new avenue to systematically understand and attack this disease. The group of speakers who have agreed to participate are some of the leading transdisciplinary investigators in these fields and are active in seeking to translate their findings to and from the clinic and the laboratory.