2005 Antimicrobial Peptides Gordon Conference

描述(由申请人提供)：第五届戈登抗菌肽研究会议将于2005年3月6日至11日在加利福尼亚州文图拉举行。抗生素耐药微生物的出现凸显了研究内源性物质的必要性。AMPS是一种内源性、基因编码的抗生素，在所研究的每个物种中都有发现，包括无脊椎动物、植物、脊椎动物和哺乳动物，包括人类。有证据表明，AMPs在多种生物环境中调节先天寄主防御。除了膜破坏机制对AMP的杀菌作用外，研究表明某些哺乳动物AMP还具有受体介导的炎症相关活性，支持AMP是多功能宿主防御效应分子的假说。了解AMPs在先天性免疫反应中的作用将有助于更好地理解人类疾病的病理生理学，包括囊性纤维化、性传播和机会性感染、牙周炎、炎症性肠病等。会议将聚焦于这一相对年轻、迅速发展的多学科研究领域。节目将分为9个环节的口头陈述和2个海报环节。所有参与者将被敦促以这些形式中的一种进行陈述。口头报告将包括Michael Zasloff教授和Robert E.W.Hancock教授的主题演讲，7个口头会议(20分钟演讲+10分钟讨论)，以及从主要海报中挑选的10个简短演讲，注意包括初级和学生参与者。新设立的职业成就奖获得者将作简短的口头陈述。口头会议的主题是：AMP多样性和系统发育、AMP合成的调节、AMP作用的机制、致病机理和微生物耐药机制、AMP模型系统和先天免疫、AMP作用的生化/生物物理参数，以及微生物对抗菌剂的反应。与会者之间有充分的时间进行有组织的讨论和非正式互动。此外，还有一节名为“热点新闻”，将专门讨论当前调查的前沿话题。组织理念是鼓励不同的参与，并关注性别问题、初级科学家、少数群体和身体有缺陷的个人。

DESCRPTION (provided by applicant):The fifth semi-annual Gordon Research Conference on Antimicrobial Peptides (AMPs) will meet in Ventura, California in March 6-11, 2005. The emergence of antibiotic-resistant microorganisms underscores the need to study of endogenous substances. AMPs are endogenous, gene-encoded antibiotics found in every species investigated, including invertebrates, plants, vertebrates, and mammals, including humans. Evidence shows that AMPs mediate innate host defense in a variety of biological settings. In addition to AMP microbicidal action by membrane disruptive mechanisms, studies show that certain mammalian AMPs also have receptor-mediated inflammation-associated activities, supporting the hypothesis that AMPs are multifunctional host defense effector molecules. Knowledge of the roles of AMPs in innate immune responses will contribute to improved understanding of the pathophysiology of human diseases, including cystic fibrosis, sexually transmitted and opportunistic infections, periodontitis, inflammatory bowel disease, and others. The conference will focus on this relatively young, rapidly expanding multidisciplinary field of study. The program will be divided into 9 sessions of oral presentations and two poster sessions. All participants will be urged to present in one of these formats. The oral presentations will include keynote addresses by Professors Michael Zasloff and Robert E. W. Hancock, 7 oral sessions (20 min lecture + 10 min discussion), and 10 short talks selected from key posters, with attention to include junior and student participants. A short oral presentation will be presented by the recipient of a newly-established Career Achievement Award. The themes of the oral sessions are: AMP Diversity and Phylogenetics, Regulation of AMP Synthesis, Mechanisms of AMP Action, Pathogenesis and Microbial Resistance Mechanisms, AMP Model Systems and Innate Immunity, Biochemical/Biophysical Parameters of AMP Action, and Microbial Responses to Antimicrobials. Ample time for organized discussion and informal interactions between participants has been included. In addition, one session, "Hot Corner and Late Breaking News" will be devoted to discussing topics at the cutting edge of current investigation. The organizational philosophy is to encourage diverse participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with physical limitations.