A proteomic approach to host humoral immune response

白色念珠菌是人类最常见的分离真菌病原体。这是一种在医院引起血液感染的常见病原体，估计死亡率为40%。高风险患者预防性抗真菌药物的使用增加，加速了耐药性的发展。迫切需要替代抗真菌疗法。避免抗真菌耐药性的一个有希望的方法是使用基于免疫的疗法。保护

Candida albicans is the most frequently isolated fungal pathogen of humans. It is a common pathogen that causes bloodstream infection in hospitals, with estimated mortality at 40%. Increased use of prophylactic antifungal drugs in high-risk patients accelerates the development of drug resistance. Alternative antifungal therapies are urgently needed. One promising approach to avoid anti-fungal resistance is to use immune-based therapies. Protective antibodies against C. albicans heat shock protein 90 (Hsp90) or beta-mannan have been shown to be active against hematogenously disseminated candidiasis in experimental mice. In particular, a human genetically recombinant antibody against the Hsp90 is currently in a multinational trial in patients with disseminated candidiasis. To identify potential vaccines and protective antibodies, we propose to develop a C. albicans protein microarray to profile humoral responses in a large number of patients with invasive candidiasis.