Fast iZQC for High Resolution MRS In Vivo

描述（由申请人提供）：本提案描述了一种从以前无法获取的器官获取高分辨率磁共振谱的方法。在大多数器官中，不均匀性使得将峰分配给化学组分变得困难和虚假，但分子间零量子相干（iZQC）对不均匀性不敏感。 iZQC的独特之处在于，它们在非均匀样品（如人体组织）中提供非常高的分辨率光谱。然而，体内分辨率增强已被证明是难以捉摸的。我们的研究结果表明，这是由于生理波动期间相对缓慢的采集的iZQC信号。这促使我们开发一种新的快速采集iZQC的方法，这将使我们能够采取许多平均值来消除这些生理波动的变幻莫测。我们提出了这个序列，沿着获得的初步结果幻影高达31倍的加速。该提案概述了我们的方法，用于更快的采集和其他改进，如水抑制，这将使我们能够将其发展为一种强大的体内技术。

DESCRIPTION (provided by applicant): This proposal describes a method to acquire high resolution magnetic resonance spectra from previously inaccessible organs. In most organs, inhomogeneity makes the assignment of peaks to chemical components difficult and spurious, but intermolecular zero quantum coherences (iZQCs) are insensitive to inhomogeneity. iZQCs are unique in that they give very high resolution spectra in inhomogenous samples, such as human tissue. Resolution enhancement in vivo, however, has proven elusive. Our results indicate that this is due to physiological fluctuations during the relatively slow acquisition of the iZQC signal. This has motivated us to develop a new fast acquisition method for iZQCs which will allow us to take many averages to mute the vagaries of these physiological fluctuations. We present this sequence, along with preliminary results acquired on phantoms for up to 31-fold speedup. This proposal outlines our method for progressing to still faster acquisitions and other improvements, such as water suppression, that will allow us to develop this into a robust technique in vivo.