Biological computation for programmed applications of biomineralized photosynthetic engineered living material (BP-ELM)

该项目旨在确定参数，以扩大低碳建筑的工程生活材料。利用一种新的光合作用介导的生物矿化过程，拟议的研究旨在生产散装固相材料使用蓝藻生物体。这为制造业创造了一个机会，创造了一个轻型、负碳的生活建筑，减少了我们建筑环境的足迹。该研究将利用生物化学工程技术实现可编程生物材料的目标。将进行生物物理（气体传输，光波长）和生物化学参数（营养物质）的生物矿化能力的蓝藻物种的生长的实验表征，以确定刺激-响应关系。动态将通过机器学习进行分析，以创建语义数据模型，并以数字方式应用于模拟BP-ELM的行为。将采用设计-建造-测试周期，通过制造按比例放大的原型来完善模型。这将确定哪些生物刺激将成为输入参数，以定义材料特性，并告知按需生长和再生。为了完成这个项目，学生将接受生物工艺放大技术和先进机器人制造的培训。该提案与Bio-ID的职权范围相一致，并且是从Tamuli先生的独立原创研究中发展出来的。EPSRC职权范围：所有项目都必须在EPSRC的职权范围内。请提供至少1个和最多3个EPSRC的研究领域，这个项目适合。研究领域的清单可在EPSRC的网站上查阅。

This project seeks to define parameters to scale up Engineered Living Materials for low-carbon construction. Using a novel process of photosynthetically mediated biomineralization, the proposed research seeks to produce bulk solid phase materials using cyanobacterial organisms. This presents a manufacturing opportunity to create light-powered, carbon negative living architecture, reducing the footprint of our built environment. The research will use biochemical engineering techniques to achieve a goal of programmable animate materials. Experimental characterisation of the biophysical (gas transfer, light wavelength) and biochemical parameters (nutrients) governing growth of the cyanobacterial species capable of biomineralisation will be conducted in order to determine the stimuli-response relationships. Dynamics will be analysed through machine learning to create a semantic data model and applied digitally to simulate the behaviour of the BP-ELM. A design-build-test cycle will be adopted to refine the model through fabrication of scale-up prototypes. This will establish which biological stimuli will become input parameters to define material properties and inform on-demand growth and regeneration.To deliver this project, the student will receive training in bioprocess scale up techniques and advanced robotic manufacturing. The proposal is aligned with the remit of Bio-ID, and has evolved out of the independent, original research of Mr.Tamuli.EPSRC remit:All projects must lie within EPSRC's remit. Please provide at least 1 and up to 3 of EPSRC's research areas that this project fits within. The list of research areas are available on EPSRC's website.