Technoeconomically Optimal and Environmentally Benign Pharmaceutical Manufacturing at High Process Mass Intensity (PMI)

爱丁堡大学（UoE）和一家大型跨国制药公司之间的这项合作研究项目将采用高保真数值建模来捕获，模拟，可视化和优化高价值活性药物成分（API）在高过程质量强度（PMI）下的生产流程的设计和操作，走向可持续和环境友好的药物生产。可行的API生产强化是可行的，通过减少溶剂的使用，然而确保稳定（例如无堵塞）有效的单元操作是最终的挑战。更高效的批次和更低的溶剂库存减少了浪费，从而提高了产量和盈利能力。这个博士项目的目的是通过计算机模拟评估溶剂选择、流程图配置（工艺合成）和库存对API工厂效率的影响：这可能是一个游戏规则改变者，使用严格的动力学参数估计和分离热力学的统一框架。产业布局和合作是这个项目的一个组成部分。

This collaborative research project between the University of Edinburgh (UoE) and a major multinational pharmaceutical company will employ high-fidelity numerical modelling to capture, simulate, visualise and optimise the design and operation of high-value Active Pharmaceutical Ingredient (API) manufacturing flowsheets at high Process Mass Intensity (PMI), towards the sustainable and environmentally benign production of medications.Viable API production intensification is feasible by reducing solvent usage, yet ensuring stably (e.g. no clogging) efficient unit operations is the resulting challenge. More efficient batches at lower solvent inventory reduce waste for higher throughput and profitability. The purpose of this PhD project is to assess in silico the effect of solvent choices, flowsheet configuration (process synthesis) and inventories on API plant efficiency: this can be a game changer, using a unified framework of rigorous kinetic parameter estimation and separation thermodynamics. Industrial placement and collaboration form an integral part of this project.