Senselab: Integration of Multidisciplinary Sensory Data

描述（由申请人提供）：本基金的主要目的是开发数据库和数据库工具，以支持实验神经科学。我们使用嗅觉通路作为模型系统，为此我们构建了一组称为SenseLab的链接数据库。我们的项目利用了三个组成项目的专业知识。项目一将开发和应用数据库的嗅觉途径的连续阶段的实验研究。这些数据库包括嗅觉受体数据库（ORDB），其中包含超过5000个化学感觉受体的档案，以及神经元数据库（NeuronDB），它记录了树突整合的膜特性。新的项目包括ORarrayDB，用于支持嗅觉受体基因表达的基因芯片分析，以及OdorMapDB，用于支持fMRI气味图谱的分析以及与各种活动制图方法生成的图谱的相关性。项目2隶属于耶鲁大学医学信息学中心，该中心为神经信息学的基础研究提供所需的专业知识，并为项目1和项目3的实验和数据库提供应用。它将扩展称为EAWCR的高度灵活的数据库结构，不仅可以增强我们的项目，还可以启动新的举措，以提供更广泛的人脑项目数据库（HBPDB）和神经科学数据库（dbfndb）之间的互操作性。项目3负责开发和维护神经元模型数据库（ModelDB），主要基于NEURON软件工具，这是一个领先的神经元集成计算建模程序。项目3将与项目1合作研究嗅觉神经元和微电路模型，并将继续开发ModelDB，超出目前存档的100个模型。本项目的结果应提供一个模型，说明相互关联的数据库如何在模型系统的实验分析中发挥重要作用，并应提供普遍适用的工具，以促进整个神经科学数据库的使用。

DESCRIPTION (provided by applicant): The main aim of this grant is to develop databases and database tools in support of experimental neuroscience. We use as a model system the olfactory pathway, for which we have constructed a set of linked databases that is called SenseLab. Our project draws on expertise in three constituent projects. Project 1 will develop and apply the databases to experimental studies of successive stages in the olfactory pathway. These databases include Olfactory Receptor Database (ORDB) with an archive of over 5,000 chemical sensory receptors, and NeuronDB, which archives membrane properties that subserve dendritic integration. New initiatives include ORarrayDB to support genechip analysis of olfactory receptor gene expression, and OdorMapDB to support analysis of fMRI odor maps and correlation with maps generated by a variety of activity mapping methods. Project 2 is under the Yale Center for Medical Informatics, which provides the expertise needed for basic research in neuroinformatics and applications to the experiments and databases of Projects 1 and 3. It will expand a highly flexible database structure termed EAWCR not only to enhance our projects but also to launch new initiatives to provide for interoperability between Human Brain Project databases (HBPDB) and neuroscience databases more broadly (DBofNDB). Project 3 is responsible for development and maintenance of a database of neuronal models (ModelDB), primarily based on the software tool NEURON, a leading program for computational modeling of neuronal integration. Project 3 will collaborate with Project 1 on studies to model olfactory neurons and microcircuits, and will continue to develop ModelDB beyond the 100 models currently archived. The results of this program project should provide a model for how interlinked databases can be essential for experimental analysis of a model system, and should provide tools of general applicability to promote the use of databases throughout neuroscience.