Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease

这个奖学金提供了一个令人兴奋的机会，加入一个由生物医学科学家和生物工程师组成的团队，利用器官芯片技术研究初级纤毛并测试新的治疗方法。该项目将测试肾脏上皮细胞中初级纤毛的药物延伸增强必要的机械转导的假设。学生将研究这是否可以补偿导致多囊肾病（PKD）的纤毛遗传破坏。

This studentship provides an exciting opportunity to join a team of biomedical scientists and bioengineers using organ-chip technology to investigate primary cilia and test new therapies. The project will test the hypothesis that pharmaceutical elongation of primary cilia in kidney epithelial cells enhances essential mechanotransduction. The student will examine whether this can compensate for the genetic disruption of cilia that causes Polycystic Kidney Disease (PKD).