Mechanisms of cell to cell spread of Marek's Disease Virus

马立克氏病是一种致命的、高度传染性的肿瘤疾病，影响鸡群，是威胁可持续食品生产的重大经济负担。它是由一种叫做Gallid herpesvirus-2或马立克氏病病毒（MDV）的甲疱疹病毒引起的。在工业化家禽养殖和蛋类疫苗接种中，通过严格的生物安全措施对该病进行管理。当前疫苗战略的失败将威胁到全球家禽生产。MDV与细胞密切相关，几乎不产生任何无细胞病毒粒子。细胞间扩散的机制尚不清楚。在这里，我们的目标是直接可视化MDV的细胞间传播，识别MDV传播所需的受体和宿主因子。我们预计，这项工作将确定宿主因素，这些因素可能成为未来建立耐mdv牲畜的目标。”

"Marek's disease is a fatal, highly contagious, neoplastic disease affecting chickens that is a significant economic burden threatening sustainable food production. It is caused by an alphaherpesvirus called Gallid herpesvirus-2 or Marek's Disease Virus (MDV). The disease is managed by tight biosecurity practices in industrial poultry forming and in ovo vaccination. Failure of the current vaccine strategy would threaten global poultry production.MDV is strictly cell-associated and produces hardly any cell-free virions. The mechanisms of cell-to-cell spread are not understood. Here we aim to directly visualise cell-to-cell spread of MDV, identify receptors and host factors that are required for MDV transmission. We anticipate that this work will identify host factors that could be targeted to establish MDV-resistant livestock in the future. "