Restoring bone regeneration in diabetic patients using ionic therapy

生物活性玻璃(BG)释放出影响骨骼再生的离子。调整特定离子(硅、钴、铁)的释放对特定的疾病状态(如高血糖-高血糖状态)可能是有益的。利用多学科的表征方法(扫描电子显微镜、透射电子显微镜、干涉测量学、拉曼光谱和微型计算机断层扫描)，本项目将研究这些离子在骨形成和吸收中的作用。此外，它还将使用在研究组内建立的新的3D体外模型来检查细胞如何吸收BG离子，以及它们在实验室培养的骨骼中的位置。为此，将使用同步加速器可用的技术，如扩展X射线吸收精细结构光谱分析(EXAFS)。

Bioactive glasses (BG) release ions that influence bone regeneration. Tailoring the release of particular ions (Si, Co, Fe) may be beneficial for particular disease states (e.g. hyperglycaemia - high glucose conditions). Using multidisciplinary characterisation approaches (scanning electron microscopy (SEM), transmission electron microscopy (TEM), interferometry, Raman spectroscopy and micro-computed tomography (Mu-CT)) this project will investigate the roles of these ions on bone formation and resorption. Additionally, it will examine how the BG ions are uptaken by the cells and where they are located within laboratory-grown bone using a novel 3D in vitro model established within the research group. For this, techniques available at the synchrotron, such as extended x-ray absorption fine structure spectrometry (EXAFS), will be used.