Core--Immune Function and Inflammation

说明(申请人提供)：背景和意义：免疫功能和 炎症核心：联席董事：查尔斯·B·斯蒂芬森博士哮喘和其他慢性疾病与少数族裔青年中的肥胖有关目前席卷美国的肥胖流行病正在影响青少年和成年人，在非裔美国人和西班牙裔青年中尤其明显(Popkin和Ury 1998；Dwyer，Stone等人)。2000)。青少年身体质量指数(BMI)的这种史无前例的增长是一种不健康的趋势，因为高BMI会增加患慢性疾病的风险，包括哮喘、2型糖尿病和心血管疾病。最近对城市非洲裔美国人和西班牙裔儿童和青少年的研究记录了肥胖与哮喘风险的这种联系(Gennuso，Epstein等人)。1998年；Luder，Melnik等人。1998年；von Mutius，Schwartz等人。2001)。这种联系是市中心儿童可能面临的哮喘负担增加的补充，这是由于暴露在不符合标准的住房中的过敏原增加(Eggleston，Rosenstreich等人)。1998年)。2型糖尿病长期以来被认为是一种与肥胖有关的成人发病疾病，现在正在青少年中被诊断出，特别是非裔美国人和西班牙裔美国人(布尔乔亚2002)。作为心血管疾病危险因素的不良健康行为(例如，高饮食胆固醇、体脂增加)在非裔美国人和 西班牙裔青少年比欧洲裔美国青少年更多(Fardy，Azz.ollini等人)。2000)。

DESCRIPTION (provided by applicant): Background And Significance: Immune Function And Inflammation Core: Co- Directors: Charles B. Stephensen, PhD. Mark Shigenaga, PhD A 1. Asthma and other chronic diseases are linked to obesity in minority youth The epidemic of obesity that is currently sweeping the U.S. is affecting adolescents as well as adults, and is particularly evident in African American and Hispanic youth (Popkin and Udry 1998; Dwyer, Stone et al. 2000). This unprecedented increase in body mass index (BMI) in adolescents is an unhealthy trend since high BMIs increase the risk of developing chronic disease, including asthma, type 2 diabetes and cardiovascular disease. Recent studies in urban African American and Hispanic children and adolescents have documented this association of obesity with asthma risk (Gennuso, Epstein et al. 1998; Luder, Melnik et al. 1998; von Mutius, Schwartz et al. 2001). This association is in addition to the increased burden of asthma that inner city children may face as a result of increased exposure to allergens in substandard housing (Eggleston, Rosenstreich et al. 1998). Type 2 diabetes, long considered an adult-onset disease associated with obesity, is now being diagnosed in adolescents, particularly African Americans and Hispanics (Bourgeois 2002). Poor health behaviors (e.g., high dietary cholesterol, increased body fat) that are risk factors for cardiovascular disease are also more prevalent in African American and Hispanic adolescents than in their European American counterparts (Fardy, Azz.ollini et al. 2000).