Super Resolution FA Retinal Imager

描述(由申请人提供)：该项目在第一阶段有两个目标：第一个目标是对现有的自适应光学眼底成像仪进行改造，以创建第一个超分辨率荧光素血管造影视网膜成像仪(SFARI)。这种改进的仪器将允许荧光素视网膜成像，空间分辨率高达3微米，在20度视野内以每秒10张图像的速度进行成像。第二个目标是使用假眼和标准参照物进行实验室测试，以定量测量这种新的SFARI设备提供的空间和时间分辨率增益，并验证该仪器用于人体受试者，并使用两名正常人演示SFARI的性能。提出的SFARI设备是在微米级空间分辨率和视频(10赫兹)帧速率的视网膜和视网膜亚结构的临床活体成像领域向前迈出的革命性一步。该项目将创新的自适应光学技术引入一项重要的新应用--荧光素血管造影术。该项目的成功完成将对眼科临床和研究做出重大贡献。荧光素血管造影术和吲哚青绿视网膜成像是大多数眼科诊所的常见程序，这使得该设备的商业潜力很大，该设备的市场包括美国和国外的所有主要眼科诊所。

DESCRIPTION (provided by applicant): The project has two Aims in Phase I. The first Aim is to modify an existing adaptive optics fundus imager to create the first Super Resolution Fluorescein Angiography Retinal Imager (SFARI) device. This modified instrument will allow fluorescein retinal imaging with up to 3 microns spatial resolution at rates of 10 images per second over a 20 deg field of view. The second Aim is to conduct laboratory testing using artificial eyes and standard references to quantitatively measure the spatial and temporal resolution gains that this new SFARI device provides and certify the instrument for use on human subjects, and to demonstrate the performance of the SFARI using two normal human subjects. The proposed SFARI device is a revolutionary step forward in the field of clinical in-vivo imaging of the retina and retinal substructures at micron-scale spatial resolutions and with video (10 Hz) frame rates. The project introduces innovative adaptive optics technology to an important new application, fluorescein angiography. Successful completion will represent a significant contribution to clinical and research ophthalmology. Fluorescein angiography and indocyanine green imaging of the retina are a common procedure in most ophthalmology clinics making the commercial potential high with the device having a market that includes every major eye clinic in the U.S. and abroad.