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Directed Delivery of Growth Factors to the CNS

Directed Delivery of Growth Factors to the CNS
生长因子定向输送至中枢神经系统
批准号：
6934761
负责人：
ANDREW BAIRD
金额：
$29.02万
依托单位：
TERA BIOTECHNOLOGY CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
项目状态：
已结题
起止时间：
2005-07-15 至 2006-06-30
来源：
https://reporter.nih.gov/project-details/6934761
关键词：
6 hydroxydopamineParkinson&aposs diseaseautoradiographybiotechnologybiotherapeutic agentblood brain barrierbrain disorder chemotherapycell proliferationcombinatorial chemistrydisease /disorder modeldrug delivery systemsdrug design /synthesis /productiondrug screening /evaluationepidermal growth factorimmunocytochemistryinhalation drug administrationlaboratory ratnerve stem cellnervous system regenerationneuropharmacologic agentnonhuman therapy evaluationphage displaypharmacokineticstransforming growth factorswestern blottings

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相关文献

中文摘要
翻译
描述(由申请人提供)：某些蛋白质，如生长因子，具有治疗神经退行性疾病的巨大潜力。因此，应该有可能刺激内源性祖细胞干细胞的生长，使它们能够增强损伤修复的自然过程。不幸的是，血脑屏障形成了一个重要的障碍，限制了大多数多肽的临床应用。我们建议应用药物生物学和组合药理学的原理来改善生长因子对大脑的输送，并描述一种综合策略来解决中枢神经系统生物疗法发展中的一个主要问题：药物对大脑的输送。
英文摘要
DESCRIPTION (provided by applicant): Certain proteins, like growth factors have significant potential to treat neurodegenerative disease. Accordingly, it should be possible to stimulate the growth of endogenous progenitor stem cells so that they could enhance the natural course of injury repair. Unfortunately, the blood brain barrier forms a significant hurdle that limits the clinical utility of most peptides. We propose to apply principles of medicinal biology and combinatorial pharmacology to improve the delivery of growth factors to the brain and describe a comprehensive strategy to address a major problem in the development of CNS biotherapeutics: drug delivery to the brain.
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会议论文
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