DETECTION SYSTEM FOR REFRACTIVE SURGERY IN DONOR EYES

描述(由申请人提供)：Vision Optimation正在提交一份第一阶段SBIR，以开发和验证一种简单、快速、可靠和敏感的软件检测工具，该工具基于角膜地形图，将识别以前接受过激光屈光手术的人类供眼。该技术必须是非侵入性的，并且不需要对地球进行过度的操作。此外，由于美国大约一半的眼睛是作为角膜巩膜边缘原位切除的，而不是整个球镜，所以它必须服从于在捐赠者床边的现场获取。目前角膜地形图包括许多用于形状分析的技术和表面表示，包括基于表面高度的系统以及基于斜率的曲率系统。每种技术都有各自的优势，我们的软件产品将适应多种技术。 本意见书的第一阶段将有两个目标。第一个目标是创建一种软件产品，将地形图作为输入，并对以前的屈光手术的存在进行预测。第二个目标是对一系列地形图上的非屈光手术角膜、近视术后屈光手术眼和远视/圆锥屈光手术后眼的理论表示进行非常定量的操作。 未来的第二阶段赠款申请将寻求通过其他研究进一步验证这一软件，这些研究包括对活体屈光手术患者的回顾研究，以及预期通过作为赠款一部分收集的一系列捐赠者眼睛。 第三阶段的进一步开发将寻求为该产品的发布和销售做准备，并探索进一步的市场，如军事飞行员飞行筛查。

DESCRIPTION (provided by applicant): Vision Optimization is submitting a Phase I SBIR to develop and validate a simple, rapid, reliable, and sensitive software detection tool, based on corneal topography that will identify human donor eyes that have had previous laser refractive surgery. The technique must be noninvasive and must not require excessive manipulation of the globe. In addition, it must be amenable to acquisition "in the field," at the donor bedside, since approximately half of eyes in the U.S. are excised in situ as corneo-scleral rims, rather than whole globes. Corneal topography currently consists of many technologies and surface representations for shape analysis, including surface height-based systems, as well as slope-based curvature systems. Each technology has individual advantages and our software product will be adaptable to multiple technologies. Phase I of this submission will have 2 objectives. The first objective is to create a software product that takes conreal topographic maps as inputs and produces a prediction as to the presence of previous refractive surgeries. The second objective is to quantitatively very to operation of the software on a serious of topographic maps with theoretical representations of non-refractive surgery corneas, post-myopic refractive surgery eyes and post-hyperopic/keratoconic refractive surgery eyes. A future Phase II grant application will seek to further validate this software through additional studies consisting of a retrospective study on living refractive surgery patients and prospectively through a series of donor eyes collected as part of the grant. Further development in Phase III will seek preparation of the product for release and sale as well as exploring further markets such as military pilot flight screening.