ANTIGEN PRESENTATION IN CEREBRAL MALARIA PATHOGENESIS: A ROLE FOR BRAIN MICROVASCULAR ENDOTHELIUM AND MICROPARTICLES

我们想更好地了解脑型疟疾期间大脑损伤是如何发生的。我们把注意力集中在脑血管内壁的细胞上，称为内皮细胞。本项目的创新之处在于将内皮细胞作为免疫细胞进行研究。我们已经证明，它们携带的分子使它们能够激活T淋巴细胞并引发炎症。了解小脑血管受损的精细机制将有助于设计更好的神经炎症治疗方法。

We want to better understand how lesions occur in the brain during cerebral malaria. We focus our attention on the cells lining the brain blood vessels, called endothelial cells. The originality of this project is to study endothelial cells as immune cells. We already showed that they carry molecules enabling them to activate T lymphocytes and trigger inflammation. Knowing the fine mechanisms by which small brain vessels become damaged will help design better treatments for neuroinflammation.