Towards broad-spectrum antimicrobial vaccines: uniting automated and enzymatic glycan assembly for the synthesis and bioconjugation of bacterial exopo

在这个项目中，我们建议在构建抗原性细菌多糖中结合两种合成复杂碳水化合物的新策略--自动化和酶促多糖组装，以开发一种使能疫苗构建的技术。迫切需要提高效力的抗体和疫苗，以及改进它们的生产方法。该项目旨在创造一种新的使能技术，用于控制合成碳水化合物-蛋白质疫苗结合物，以寻求广谱抗菌疫苗。

In this project we propose to unite two novel strategies for synthesis of complex carbohydrates, automated and enzymatic glycan assembly, in the construction of antigenic bacterial polysaccharides for the development of an enabling technology for vaccine construction. There is a pressing need for antibodies and vaccines of improved efficacy, and improved methods for their production. This project is aimed at creating a new enabling technology for controlled synthesis of a carbohydrate-protein vaccine conjugate in pursuit of a broad-spectrum antimicrobial vaccine