Advanced Optical Techniques to Probe the Effect of Molecular Crowding on Lipid Membrane Dynamics

在约克开发的尖端单分子技术现在第一次可以应用于解决以前涉及囊泡构象和活性的棘手生物学问题。此外，这名博士生将与Quinn密切合作，在系内建立一个新的超快光谱设施，这也将使内部(Krauss，Wang，Cavill，Kröger)和外部(Johnson，Leech，Moore，Baumann)的学者受益。这项工作还将为EPSRC支持奎恩(2022年)的主要早期职业奖学金提供种子，在EPSRC优先领域至少2个EPSRC响应模式投标(每个约500k)，并将在3年以上的时间框架内支持Leake和Quinn之间的可持续合作。我们还要求一名博士生完成实验，以支持至少1篇即将发表的高影响力论文和2-4篇未来的出版物。鉴于生命物理团队和新实验室最近的增长，该项目还将为该部增加实质性价值，并将加强与约克生物医学研究所以及多个部门的其他机构的联系。在写这篇文章的时候，我们已经收到了四份来自潜在博士生的申请，他们都是非常积极和有能力的人，其中三人有望获得优秀的一等奖。然而，所有候选人都依赖于资金。请注意，在撰写这份申请书时，Steve Quinn博士正在监督他在约克大学的第一个博士生(2020-2023年)，Leake教授将在这一令人兴奋的研究计划中为他和候选人提供支持。

The state-of-the-art single-molecule technologies developed in York can now, for the first time, beapplied to address previously intractable biological questions involving vesicle conformation and activity.Furthermore, the PhD student will work closely with Quinn to establish a new ultrafast spectroscopy facility withinthe Department which will also serve to benefit internal (Krauss, Wang, Cavill, Kröger) and external (Johnson, Leech,Moore, Baumann) academics. The work will also seed a major EPSRC Early Career Fellowship in support of Quinn(2022), at least 2 EPSRC responsive mode bids (ca. £500k each) in EPSRC priority areas and will afford asustainable collaboration between Leake and Quinn over a 3+ year timeframe. We also require a PhD student tocomplete experiments in support of at least 1 imminent high impact paper and 2-4 future publications. This projectwill also add substantive value to the department given the recent growth of the Physics of Life team and newlaboratories, and will strengthen links with the York Biomedical Research Institute, as well as others across multipledepartments. At the time of writing, we have received four applications from potential PhD students, all of whom arehighly motivated and competent individuals, and three of whom are on target for excellent 1st class awards. Allcandidates are, however, reliant on funding. Please note at the time of writing this application, Dr. Steve Quinn is inthe process of supervising his first PhD student at York (2020- 2023) and Prof. Leake will act in capacity of supportinghim and the candidate throughout this exciting programme of research.