Investigating the mechanism of the bacterial protection system MsrP/Q using EPR spectroscopy

甲硫氨酸亚砜还原酶MsrP和MsrQ在保护细菌（包括主要的人类病原体）免受活性氧和氯物种的侵害中起重要作用。然而，它们的作用机制还不清楚。在这个项目中，我们将采用电子顺磁共振（EPR）技术来识别和理解自由基物种在这些复杂的反应中的作用。此外，开发的新方法来研究MSRP/Q系统预计将更普遍适用于氧化还原活性酶。

The methionine sulfoxide reductases MsrP and MsrQ play an important role in protecting bacteria, including major human pathogens, against reactive oxygen and chlorine species. However, their mechanism of action is not well understood. In this project, we will employ electron paramagnetic resonance (EPR) techniques to identify and understand the role of radical species in these complex reactions. Moreover, the novel methodology developed to study the MsrP/Q system is anticipated to be more generally applicable to redox-active enzymes.