Treatment of Complex Patients: Emphasis on Nicotine

描述(由申请人提供)： 这项K05建议的总体目标是支持和扩大我在药物滥用，特别是尼古丁依赖治疗方面的研究，以进一步提高我指导初级科学家的能力，使我能够继续在科学领导和向临床社区传播研究成果方面。我的兴趣集中在药物依赖的治疗上，特别是尼古丁依赖作为一种慢性、复发性疾病。我还对滥用药物的共病感兴趣。我将完成两项R01资助，重点是延长吸烟治疗：(1)长期吸烟者延长行为复发预防和安非他酮治疗的研究；(2)老年吸烟者延长的、特定年龄的复发预防和尼古丁替代治疗的研究。我将继续指导P50中心的拨款，重点是复杂患者的混合治疗。我的中心部分，共病吸烟者的治疗，在一家精神科门诊诊所研究了一种针对抑郁吸烟者的创新干预措施，并确定了干预的效果和成本效益。我还将完成一项由加利福尼亚州资助的关于对虚弱老年吸烟者进行干预的试点研究。在该奖项的后几年，我将发展和提出作为正在进行的工作的合乎逻辑的延伸的研究。我将继续指导药物滥用治疗和服务研究的博士后培训计划，并参与其他研究培训计划，并将成果传播给临床社区。该奖项将让我有时间和支持我从事研究项目，进一步发展目前在吸烟、抑郁症、抗抑郁药物和心理治疗方面的工作，花适当的时间指导初级教师，继续参与中心拨款和其他合作机制，并完善我的方法技能，向专业团体传播研究成果。

DESCRIPTION (provided by applicant): The overall goal of this K05 proposal is to support and extend my research in the treatment of drug abuse, especially nicotine dependence, to further my capacity to mentor junior scientists, to allow me to continue in scientific leadership and dissemination of research findings to the clinical community. My interests focus on the treatment of drug dependence, especially nicotine dependence as a chronic, relapsing disorder. I am also interested in comorbidities across drugs of abuse. I will complete two R01 grants that focus on extended treatment of cigarette smoking: (1) a study of extended behavioral relapse prevention and bupropion treatment for chronic smokers; (2) a study of extended, age-specific relapse prevention and nicotine replacement treatment for older smokers. I will continue to direct a P50 center grant that focuses on Blended Treatments for Complex Patients. My center component, Treatment of Comorbid Smokers, studies an innovative intervention for depressed smokers in a psychiatric outpatient clinic, and determines the efficacy and cost-effectiveness of the intervention. I will also complete a pilot study funded by the state of California on interventions for frail elderly smokers. In later years of this award, I will develop and propose studies that are logical extensions of ongoing work. I will continue to direct a postdoctoral training program in drug abuse treatment and services research, and participate in other research training programs, and will disseminate results to the clinical community. The award will allow me time and give me support to pursue research projects that further current work in smoking, depression, antidepressants, and psychotherapy, to spend appropriate time mentoring junior faculty, to continue my involvement in center grants and other collaborative mechanisms, and to refine my methodological skills and disseminate research findings to the professional community.