Extramural Res Facilities Construction-Behavioral Neuro*

描述（由申请人提供）： 该C06建设补助金申请由伊利诺伊大学芝加哥分校（UIC）提交，旨在翻新约平方英尺的研究空间，为行为神经生物学高级研究中心（CARBN）创造研究环境。UlC是NIH指定的西班牙裔卓越中心和DHHS指定的女性健康卓越中心。该空间位于伊利诺伊州立精神病学研究所的现有设施内，该研究所建于1959年，并于1997年转移到UlC。该提案要求提供资金进行翻新，使现有的实验室设施达到现行标准，并建立新的实验室，用于测试动物和人类的行为。自大楼建造以来，拟议翻修的空间没有进行过改造或升级。UIC最近投资开发了一个最先进的6300平方英尺的动物设施，该设施毗邻计划中的改造。行为神经生物学是生物医学研究的重要领域，也是转化研究的主要领域。UIC有一个迅速扩大的行为神经生物学研究计划，但没有足够的实验室设施来支持这一增长。CARBN的组织促进了一个互动的合作环境，在这个环境中，基本的神经科学技术可以应用于行为和心理过程的研究。CARBN的目标是通过最初关注社会行为和情绪调节的神经生物学来更好地理解精神障碍的机制，因为社会行为和情绪调节的缺陷是几种精神障碍的核心特征。拟议的建设将扩大人类神经生物学的研究，并鼓励集中研究专业知识和共享研究设备。CARBN的一个特别优势是强调进行转化研究，将基本的神经科学技术应用于临床研究问题，并开发新的基于生物学的评估和治疗。CARBN还将为临床实践和研究提供一种机制，以告知行为神经生物学理论。在CARBN进行的研究将涉及从分子生物学到行为的动物模型，以及临床和正常人群的研究。改造后的空间将包括实验室，容纳大约8个研究团队，每个团队都代表了CARBN的主要重点。每个小组将由几名调查员组成。长期目标是提供基础设施，以提高UIC行为神经生物学研究的范围和质量。

DESCRIPTION (provided by applicant): This C06 Construction Grant application, submitted by the University of Illinois at Chicago (UIC), is to renovate approximately square feet of research space to create a research environment for the Center for Advanced Research in Behavioral Neurobiology (CARBN). UlC is a NIH-designated Hispanic Center of Excellence and a DHHS-designated Center of Excellence for Women's Health. The space is located in an existing facility that formerly housed the Illinois State Psychiatric Institute, which was constructed in 1959 and transferred to UlC in 1997. The proposal requests funds for renovations that will bring existing laboratory facilities to current standards and build new laboratories that are designed for the testing of behavior in animals and humans. The space proposed to be renovated has not been modified or upgraded since the construction of the building. UIC has recently invested in the development of a state-of-the-art, 6300 square foot animal facility, which is adjacent to the planned renovation. Behavioral neurobiology is a vital area of biomedical research and a primary area of translational research. UIC has a rapidly expanding behavioral neurobiology research program, but does not have adequate laboratory facilities to support this growth. The organization of CARBN promotes an interactive collaborative environment in which basic neuroscience techniques can be applied to the study of behavioral and psychological processes. The goal of CARBN is to better understand the mechanisms of mental disorders by initially focusing on the neurobiology of social behavior and emotion regulation, since deficits in social behavior and emotion regulation are a core feature of several psychiatric disorders. The proposed construction will expand research in human neurobiology and encourage centralization of research expertise and shared research equipment. A particular strength of CARBN is an emphasis on conducting translational research, which will apply basic neuroscience techniques to clinical research questions and develop new biologically based assessments and treatments. CARBN will also provide a mechanism for clinical practice and research to inform behavioral neurobiology theory. Research to be conducted in CARBN will involve animal models, ranging from molecular biology to behavior, and studies with clinical and normal human populations. The remodeled space will include laboratories to house approximately 8 research teams, each representing a major emphasis of CARBN. Each team will consist of several investigators. The long-term objective is to provide the infrastructure for improving the scope and quality of behavioral neurobiology research at UIC.