CRH-binding Protein: A Regulator of CRH in Stress

描述(由申请者提供)：焦虑症和抑郁症属于 最常见的精神障碍。这些病症的病因是 未知，但可能暴露于压力和无法应对压力 导致这些疾病的发展。失调症 促肾上腺皮质激素释放激素系统与抑郁症和 某些焦虑症，使它很可能是压力与 这些障碍。促肾上腺皮质激素释放激素及其受体在调节 压力反应。最近的研究表明，CRH结合蛋白(CRH-BP)可能 在压力中也起到一定作用。有证据表明CRH-BP在局部结合 释放CRH并阻止其在CRH受体上的作用。CRH-BP因此可用于 维持CRH系统的动态平衡，从而限制应激反应。 尽管如此，CRH-BP仍然是CRH系统中一个鲜为人知的组成部分。 拟议的研究将集中在CRH-BP相互作用的性质上 在压力下大脑中的CRH和CRH受体。对…的考试 CRH-BP的应激诱导调节和功能可能被证明是有用的 了解与压力相关的精神病理学的潜在机制，并可能导致 寻找CRH调节失调的新治疗方法 系统。

DESCRIPTION (provided by applicant): Anxiety disorders and depression are among the most common psychiatric disorders. The etiology of these conditions is unknown, but exposure to stress and an inability to cope with stress likely contribute to the development of these disorders. Dysregulation of the corticotropin-releasing hormone (CRH) system is associated with depression and certain anxiety disorders, making it a likely candidate for linking stress to these disorders. CRH and its receptors are known to play a role in mediating the stress response. Recent work suggests that CRH-binding protein (CRH-BP) may also play a role in stress. Evidence suggests that CRH-BP binds locally released CRH and prevents its action at CRH receptors. CRH-BP may thus serve to maintain homeostasis in the CRH system, thereby limiting the stress response. Despite this, CRH-BP remains a poorly understood component of the CRH system. The proposed research will focus on the nature of the interactions of CRH-BP with CRH and CRH receptors within the brain during stress. An examination of the stress-induced regulation and function of CRH-BP may prove useful in understanding mechanisms underlying stress-related psychopathology and may lead to new treatment approaches for disorders involving dysregulation of the CRH system.