Prediction and Prevention of Type I Diabetes

描述（由申请人提供） 这是孩子们的意见书吗匹兹堡大学附属医院 针对TrialNet RFA。这组调查人员与广泛的 根据经验，制定了四个具体目标， TrialNet RFA。具体目标1扩展了DPT-1目前的口服手臂。 具体目标2建议使用T细胞免疫学来评估 TrialNet中免疫干预的有效性。具体目标3涉及 所筛选对象的社会心理和教育需求的重要问题， 包括在干预研究中。具体目标4是一项试点研究 具有潜在安全有效性高亲和力肽， 防止自身免疫的发展。 应用程序的优势在于其专业知识和经验， 研究人员和三个中心的良好合作。

DESCRIPTION (provided by applicant) This is a submission from the Children?s Hospital and University of Pittsburgh in response to the TrialNet RFA. This group of investigators with extensive experience has formulated four specific aims that answer all the objectives of the TrialNet RFA. Specific Aim 1 extends the current oral arm of DPT-1. Specific Aim 2 proposes the use of T-cell immunology to assess the effectiveness of immune interventions in TrialNet. Specific Aim 3 addresses the important issue of psychosocial and educational needs of subjects screened and included in intervention studies. Specific Aim 4 is a pilot study of a high-affinity peptide with potential safe effectiveness for delaying or preventing progression of autoimmunity. The strength of the application is the expertise and experience of the investigators and well established collaboration across three centers.