UCSF PROSTATE CANCER SPORE

申请人的描述该申请代表了改善前列腺癌预防、诊断和治疗的跨学科方法。 UCSF基础科学家和临床研究人员在细胞和分子生物学，免疫学，遗传学以及信息学，生物统计学方面具有不同的才能，并在前列腺癌中进行I期研究，他们正在共同努力解决这种疾病的重要问题。 四个项目专门设计用于改善晚期前列腺癌的治疗，使用1）抗CTLA 4抗体2）突变腺病毒和放射治疗，3）抗前列腺癌抗原的重组人抗体，和4）突变端粒酶。 其中一个项目将使用抗体基因多样性文库和噬菌体展示来鉴定新的前列腺癌抗原。 此外，一个项目的重点是确定前列腺癌中导致疾病发展和进展的遗传畸变。 一个相关的项目集中在识别决定患者是否发生前列腺癌转移的修饰基因。 几个核心将为项目提供关键支持，包括重点关注的核心：信息学，临床研究，动物技术;组织采集和储存，以及管理。此外，最近成立的前列腺癌倡导核心的成员将与SPORE研究人员合作，设计和实施临床试验的最佳方法。

APPLICANT'S DESCRIPTION The application represents an interdisciplinary approach to improving prevention, diagnosis, and treatment of prostate cancer. UCSF basic scientists and clinical investigators with diverse talents in cell and molecular biology, immunology, genetics, as well as informatics, biostatistics, and conducting phase I studies in prostate cancer are working together to address important problems in this disease. Four projects specifically are designed to improve treatment of advanced prostate cancer using either 1) anti-CTLA4 antibodies 2) mutant adenoviruses and radiation therapy, 3) recombinant human antibodies against prostate cancer antigens, and 4) mutant telomerases. One of the projects will identify new prostate cancer antigens using antibody gene diversity libraries and phage display. In addition, one project is focused on identifying the genetic aberrations in prostate cancer responsible for development and progression of the disease. A related project is focused on identifying modifier genes which determine whether patients develop prostate cancer metastases. Several Cores will provide critical support to the Projects including Cores focused on: Informatics, Clinical Research, Animal Technology; Tissue acquisition and storage, and Administration. In addition, members of a recently formed Prostate Cancer Advocacy Core will work with SPORE investigators to design, and implement optimal approaches to clinical trials.