How does disruption of Serinc1 expression affect lymphocyte function and the development of autoimmunity?

自身免疫性疾病影响高达8%的人口。我们最近在小鼠中发现了一种新的基因突变，导致抗核抗体水平增加，这是人类各种自身免疫性疾病的标志。突变的基因Serinc1以前没有涉及自身免疫性疾病，但它对免疫细胞中关键分子的合成很重要。这项研究旨在确定Serinc1的破坏如何促进自身免疫性疾病的发展。

Autoimmune diseases affect up to 8% of the population. We have recently discovered a novel gene mutation in mice that results in increased levels of anti-nuclear antibodies, a hallmark of various autoimmune diseases in humans. The mutated gene, Serinc1, has not been previously implicated in autoimmune disease, but it is important for synthesis of key molecules in immune cells. This research proposal aims to determine how disruption of Serinc1 contributes to the development of autoimmune disease.