The Variable Expression of CD33 on Leukemic Stem Cells

描述(申请人提供)：这是一份K08奖项的申请表。候选人是密歇根大学医学中心血液和骨髓移植项目的初级教员。贝克尔博士的长期目标是成为白血病发生和干细胞生物学领域的独立实验室研究员。这份申请详细说明了一项四点计划，该计划将为贝克尔博士发展他的研究生涯提供必要的工具，以便他能够实现这一目标。 首先，贝克尔博士将通过参加密歇根大学研究生院的几门课程，获得分子生物学和发育生物学方面的高级概念和理论培训，重点是癌症发生和干细胞生物学。 其次，贝克尔博士将通过完成他的关于急性髓系白血病白血病干细胞上CD33表达的研究项目，获得更多的研究技能和技术。贝克尔博士已经取得了令人印象深刻的初步数据，这些数据已提交给一家领先的同行评议期刊发表。 第三，Becker博士将通过参加BMT研究研讨会和会议、参加全国会议和准备手稿，获得成功职业生涯所需的高级书面和口头沟通技能。 第四，申请者在整个奖项过程中的进展将受到一个由资深研究人员和学术领袖组成的咨询委员会的监督。申请者的赞助人保证贝克尔博士80%的努力将在本奖项期间致力于他的研究。

DESCRIPTION (provided by applicant): This is an application for a K08 award. The candidate is a junior faculty member in the Blood and Marrow Transplantation Program at the University of Michigan Medical Center. Dr. Becker's long term goal is to become an independent laboratory investigator in the field of leukemogenesis and stem cell biology. This application details a four point program that will provide the necessary tools for Dr. Becker to develop his research career such that he can achieve this goal. First, Dr. Becker will obtain advanced conceptual and theoretical training in molecular biology and developmental biology with particular emphasis on carcinogenesis and stem cell biology by participating in several courses in the University of Michigan graduate school. Second, Dr. Becker will acquire additional research skills and techniques through the completion of his research project regarding the expression of CD33 on leukemic stem cells in Acute Myelogenous Leukemia. Dr. Becker has already achieved impressive preliminary data that have been submitted for publication in a leading peer reviewed journal. Third, Dr. Becker will acquire advanced communication skills, both written and oral, required for a successful career through participation in BMT research seminars and conferences, participation in national meetings and the preparation of manuscripts. Fourth, the applicant's progress throughout the award will be monitored by an advisory committee of senior researchers and academic leaders. The applicant's sponsor guarantees that 80% of Dr. Becker's effort will be devoted to his research for the period of this award.