How does T cell receptor signaling begin?

T细胞活化的初始步骤，即外部配体结合如何转化为细胞质侧受体磷酸化的增加，仍然知之甚少。据信，癌症中免疫识别的丧失和自身免疫性疾病中的过度反应性是由这种跨膜信号转导的异常引起的。阐明这一分子机制可以为这些疾病提供分子基础，并为更有效的治疗提供指导。

The initial step of T cell activation of how the external ligand binding is translated to an increase of receptor phosphorylation at the cytoplasmic side is remain poorly understood. It is believed that the loss of immune recognition in cancer and over reactivity in auto-immune diseases are caused by abnormality of this transmembrane signalling transduction. Clarification of this molecular machinery can provide a molecular basis of those diseases and guidelines of more effective therapies.