Evolving cyclopropane fatty acid synthase (CFAS) enzymes into biocatalysts for the synthesis of cyclopropane containing drugs and chemicals

该项目是GSK与伦敦国王学院的Daniele Castagnolo博士（DC）之间的一项新合作，旨在对环丙烷脂肪酸合酶（CFAS）进行表征和工程改造，将其转化为生物催化剂，通过更可持续的工业流程合成含环丙烷的药物和化学品。该项目完全符合BBSRC的战略优先事项“工业生物技术的新战略方法”。

This project is a new collaboration between GSK and Dr Daniele Castagnolo (DC) at King's College London and is aimed at the characterization and engineering of cyclopropane fatty acid synthase (CFAS) enzymes to turn them into biocatalysts for the synthesis of cyclopropane containing drugs and chemicals through more sustainable industrial processes. The project fully aligns with the BBSRC strategic priority "New strategic approaches to industrial biotechnology".