ALZHEIMER'S DISEASE RESEARCH CENTER

简介（由申请人提供）：过去的四年是UAB阿尔茨海默病研究中心（ADRC）发展壮大的时期。这一申请代表了我们继续ADRC额外五年的请求。该ADRC由5个核心和3个小项目组成。行政核心将提供ADRC所有目标的实施，包括预算、执行委员会、内部和外部咨询委员会会议、通过试点赠款（即为AD研究引入新的研究人员）、每月系列研讨会以及与其他阿尔茨海默病中心的互动来提高知名度。临床核心将继续跟踪先前招募的患者，每年招募30名对照组，30名轻度认知障碍（MCI）， 30名轻度AD和30名帕金森病合并痴呆（PDD）患者。将进行年度神经心理学评估和尸检安排。数据管理和生物统计核心将提供统计咨询，数据管理和发送所有必要的信息给NACC。神经病理学核心将提供诊断、处理和储存组织（脑、脑脊液）的新技术，并将这些技术提供给UAB和其他机构的研究人员。教育和信息传递核心将为医生、辅助专业人员和非专业社区（重点是非裔美国人）提供教育，维护演讲者局、护理人员通讯、AD信息包，继续我们的年度CME课程，与皇家中心一起完成其他课程，维护我们的网页，并通过多媒体传播ADRC研究。这三个项目通过研究AD， PDD和MCI患者及其护理人员的行为，纵向和功能变化而在主题上联系在一起。其中一个项目将检查轻度认知损伤患者与正常老年人的功能变化（如驾驶）。第二个项目将审查AD、PDD和控制方面医疗决策能力的丧失。第三个项目将确定，当“所爱的人”仍患有轻度阿尔茨海默病时，照顾者的干预是否会改善照顾者在“所爱的人”发展为中度/重度阿尔茨海默病时的适应能力。行政当局在思想上和财政上都大力支持民主改革委员会，支付署长的薪金，并为民主改革委员会翻修许多领域。在UAB继续开展ADRC将使我们能够继续在AD的临床和基础研究工作，并使我们能够扩展到新的研究领域（例如PDD， MCI）。

DESCRIPTION (provided by applicant): The past four years have been a time of development and growth of the Alzheimer's Disease Research Center (ADRC) at UAB. This application represents a request to continue our ADRC for an additional five years. This ADRC is composed of 5 Cores and 3 small projects. The Administrative Core will provide the implementation of all goals of the ADRC including budgets, meetings of the Executive and Internal and External Advisory Committees, enhancing visibility through pilot grants (i.e. bring new investigators to AD research), a monthly seminar series and interactions with other Alzheimer's Disease Centers. The Clinical Core will continue to follow previously recruited patients and recruit 30 controls, 30 mild cognitive impairment (MCI), 30 mild AD, and 30 Parkinson's Disease with dementia (PDD) patients annually. Annual neuropsychological assessments and arrangement for autopsy will be performed. The Data Management and Biostatistics Core will provide statistical consultation, data management and send all required information to the NACC. The Neuropathology Core will provide new techniques for diagnosis, process and store tissue (brain, CSF) and make these available to investigators at UAB and other institutions. The Education and Information Transfer Core will provide education to physicians, paraprofessionals and lay communities (with emphasis on African-Americans), maintain a Speakers Bureau, caregivers' newsletters, packets of information on AD, continue our annual CME courses with every other one done in conjunction with the Roybal Center, maintain our web page and disseminate ADRC research through multimedia. The 3 Projects are thematically linked by studying behavioral, longitudinal and functional change in AD, PDD and MCI patients and in caregivers. One Project will examine functional (e.g. driving) change in MCI patients as compared to normal older adults. A Second Project will examine the loss of medical decision making capacity in AD, PDD and controls. A Third Project will determine if interventions with caregivers while their "loved one" still has mild AD will improve caregivers' adjustment when their "loved one" progresses to moderate/severe AD. The Administration strongly supports the ADRC both philosophically and financially, paying the salary of the Administrator as well as renovating multiply areas for the ADRC. Continuation of an ADRC at UAB would allow us to continue both clinical and basic research efforts in AD and would allow us to expand into new research areas (e.g. PDD, MCI).