Ohio State Neuroscience Center Core

描述（由申请人提供）： 人类神经系统疾病的关键见解已经通过使用模型遗传生物体收集。该NINDS中心核心提案的主要目的是增强研究者对俄亥俄州各种动物模型系统的访问。16名合格的研究人员已经确定，构成拟议的俄亥俄州国家NINDS神经科学中心。该小组不仅汇集了对动物和转基因模型的共同需求，以研究大脑发育，功能，疾病和损伤，而且还汇集了各种各样的协同专业知识。还确定了中心用户（不符合国家土著发展战略赠款持有者）的广泛基础。该中心核心提案的目的有几个方面：支持当前NINDS资助的调查人员，促进这些调查人员之间的互动项目，为俄亥俄州校园周围的其他NINDS资助的核心用户提供支持，并促进整个大学的基础和翻译研究人员之间的互动。需要遗传学核心以及啮齿动物行为，电生理学和共聚焦显微镜核心。构成该中心的合格项目包括脊髓损伤和再生，生长锥指导，大分子的轴突和树突运动，亨廷顿病兴奋性毒性的机制，脊髓性肌萎缩症的遗传学，实验性中风的结果和恢复，等等。NINDS资助的用户群中采用动物和转基因模型的其他项目包括细胞周期控制机制、皮质乙酰胆碱定向注意力控制机制和病毒性脑炎中的细胞应激反应。

DESCRIPTION (provided by applicant): Key insights into human neurological disorders have been gleaned through the use of model genetic organisms. The main purpose of this NINDS Center Core proposal is to enhance investigator access to a variety of animal model systems at Ohio State. Sixteen qualifying investigators have been identified that constitute the proposed Ohio State NINDS Neuroscience Center. This group brings together not only a common need for animal and transgenic models to study brain development, function, disease, and injury, but also a diverse spectrum of synergistic expertise. A broad base of Center users (non-qualifying NINDS grant holders) has also been identified. The aims of this Center Core proposal are several fold: to support current NINDS-funded investigators, to facilitate interactive projects amongst these investigators, to provide support for other NINDS-funded Core users around the Ohio State campus, and to facilitate interactions amongst basic and translational researchers throughout the University. A Genetics Core as well as Rodent Behavior, Electrophysiology, and Confocal Microscopy Cores are requested. Qualifying projects that make up the Center include spinal cord injury and regeneration, growth cone guidance, axonal and dendritic movements of macromolecules, mechanisms of Huntington's disease excitotoxicity, the genetics of spinal muscular atrophy, experimental stroke outcome and recovery, and many more. Additional projects in the NINDS-funded user base that would employ animal and transgenic models include mechanisms of cell cycle control, mechanisms of cortical ACh-directed attentional control, and the cellular stress response in viral encephalitis.