Behavior Genetics of Temperament and Psychopathology

描述（由申请人提供）：有大量关于儿童气质特征和精神症状界面的文献。最近的一项荟萃分析表明，情绪性的气质特征与内化和外化障碍适度相关。然而，这些关联的病因在很大程度上是未知的。拟议的项目将研究遗传和环境的影响，潜在的情感和内化和外化症状之间的关联。来自格鲁吉亚双胞胎登记处的数据，一个基于人口的样本，838对4 - 18岁的双胞胎，将用于解决几个具体的目标。这些数据将允许行为遗传分析的情绪性和行为学，以及情绪性和每个症状维度之间的协变分析。先前的研究尚未阐明情绪性与内化和外化障碍之间的关联是否是由于共同的潜在遗传或环境影响。拟议的研究将作出独特的贡献，发展精神病理学文献阐明这些协会的性质，使用多元行为遗传模型拟合分析。

DESCRIPTION (provided by applicant): There is a large body of literature on the interface of childhood temperament characteristics and psychiatric symptoms. A recent meta-analysis indicates that the temperamental characteristic of emotionality is moderately associated with both internalizing and externalizing disorders. The etiology of these associations, however, are largely unknown. The proposed project will examine the genetic and environmental influences underlying the associations between emotionality and internalizing and externalizing symptoms. Data from the Georgia Twin Registry, a population-based sample of 838 twins age 4 - 18, will be used to address several specific aims. These data wilt allow for behavior genetic analyses of both emotionality and symptomatology as well as analyses of covariation between emotionality and each symptom dimension. Previous studies have not yet elucidated whether the associations between emotionality and internalizing and externalizing disorders are due to common underlying genetic or environmental influences. The proposed study will make a unique contribution to the development psychopathology literature by elucidating the nature of these associations using multivariate behavior genetic model-fitting analyses.