Synthesis of Spiro-Azetidines via Photoinduced Strain Release of Azabicyclo

该项目属于EPSRC合成有机化学研究领域。螺环是药物化学中的特权结构，因为它们具有刚性、高SP3含量和易于进入未探索的三维化学空间。螺环分子，特别是螺氮杂环类化合物，已被证明是药物相关基团的有价值的生物等位基因，如吗啡和哌啶类化合物，代谢稳定性和蛋白质结合显著改善。

This project falls within the EPSRC Synthetic Organic Chemistry research area.Spirocycles are privileged structures in medicinal chemistry due to their rigidity, high sp3 content and ease of access to unexplored three-dimensional chemical space. Spirocyclic molecules, and in particular spiroazetidines, have proved to be valuable bioisosteres for medicinally relevant groups such as morpholines and piperidines with metabolic stability and protein binding being improved significantly.