CORE--EPIDEMIOLOGY, DATA MANAGEMENT AND STATISTICS

流行病学、数据库管理和统计(EDMS)核心将为项目和其他核心提供中央流行病学、数据管理和生物统计资源。EDMS核心将通过每周与其他核心领导人和项目协调员举行会议来参与核心到核心的活动，以审查和讨论所有与数据有关的问题，包括队列跟踪和保留、数据完整性和数据检索。核心有三个组成部分。其他每个核心和研究项目产生的数据将转移到数据库部分，以便输入和存储在综合SIR/DBMS数据管理系统中，该系统旨在满足方案项目在清理、组织和检索用于计划分析的数据方面的所有需要。的活动 数据库部分将在专门为数据管理业务配置的计算机联网系统上进行。流行病学部分将在流行病学方法、假设检验以及研究结果的解释和陈述方面提供专家咨询。它将就方法问题提供指导，例如关于风险因素、结果和相关变量的主题分类、制定 派生变量、匹配、偏差和混杂。这些活动将通过与核心统计员和个别项目调查员轮流举行每两周一次的会议以及项目调查员每月举行一次联席会议的方式进行，以审查编写中的手稿。统计部分将负责规划和执行调查人员进行的所有分析。核心统计，与临床和 脑成像核心将提供与认知和功能表现以及脑成像结果相关的共同汇总结果衡量标准，并将采用一套核心策略来分析对项目构成常见问题的大型预期多变量和多变量纵向数据集。通过将数据管理、流行病学和统计监督集中在EDMS核心，我们将确保一致性和促进 项目在统一变量定义、数据汇总、测试选择、模型建立和研究结果解释方面的互动。

The Epidemiology, Database Management, and Statistics (EDMS) Core will provide the central epidemiologic, data management and biostatistical resources for the projects and other Cores. The EDMS Core will participate in Core-to-Core acitvities by weekly meetings with the other Core leaders and the the program coordinator to review and discuss all data-related issues, including cohort follow-up and retention, data completeness, and data retrival. The Core has three components. Data generated by each of the other cores and research projects will be transferred to the Database Component for entry and storage in an integrated SIR/DBMS data management system designed to meet all the needs of the program project with respect to cleaning, organization and retrieval of data for planned analyses. The activities of the Database Component will be carried out on a networked system of computers especially configured for data management operations. The Epidemiology Component will provide expert consultation in epidemiolgic methods, hypothesis testing, and in the interpretation and presentation of research findings. It will provide guidance on methodological issues such as subject classification on risk factor, outcome and related variables, development of derived variables, matching, bias and confounding. These activities will be carried out by means of bi-weekly meetings with Core statisticians and individual project investigators on a rotating basis and by a monthly joint meeting of project investigators to review manuscripts in preparation. The Statistics Component will be responsible for the planning and implementation of all analyses conducted by investigators. Core Statisticans, in collaboration with the Clinical and Brain Imaging Cores, will provide common summary outcome measures related to cognitive and functional performance, and to brain imaging results and will employ a core set of strategies for the analysis of large prospective multivariable and multivariate longitudinal datasets that pose common problems for the projects. By centralizing data management, epidemiological and statistical oversight in the EDMS Core, we will ensure the consistency and facilitate interaction of the projects with respect to uniform definitions of variables, data summarization, choice of tests, model building and interpretation of study results.