Cellular/Molecular Basis of Development: Research Center

描述(由申请人提供)：通过RCMI倡议，纽约城市学院创建了发育的细胞和分子基础研究中心(CSCMBD)。该中心建立在学院在RCMI支持的领域的现有优势的基础上，通过增加新的活跃研究的教员而得到丰富。目前有25名研究人员参加了该中心的研究，分成3个科学领域：(区域组I)生物分子 结构和功能，(区域组II)基因表达和调控，以及(区域组III)神经生物学。除了主要的科学领域外，该中心的教职员工的独特技能被集结起来，以发展一个艾滋病小组。主要设备的采购和中央设施的建立进一步加强了中心内的活动。在这个应用程序中，我们将重新组织我们的程序。对我们上一次申请的一(1)项批评是，第二区域太大，看起来杂乱无章。经过多次讨论，我们建议将其成员重组为两个新的研究领域。II区的成员要么留在II区的癌症发展新焦点(细胞周期和信号转导)下，要么成为IV区的成员，这将是我们的免疫学小组。我们将不再有艾滋病小组。我们建议继续通过聘用研究活跃教师来加强我们目前的研究中心 会员。这个应用程序的主要重点是为每个领域聘请一名科学家。我们提议雇用1名X射线结晶师(I区)、1名癌症(细胞周期和信号转导)(II区)科学家、1名神经生物学家(III区)和1名免疫学家(IV区)。我们要求更换旧的FACS分类器，并购买共焦显微镜。这项申请还包括申请资金，以更新或更换我们的核心设施中使用的过时设备，并要求资金支持几个核心设施项目的合同。

DESCRIPTION (provided by applicant): Through the RCMI initiative the City College of New York created the Center for the Study of the Cellular and Molecular Basis of Development (CSCMBD). The Center, built on the existing strengths of the College in the RCMI-supported areas, was enriched by the addition of new research active faculty members. There are now 25 researchers participating in the Center grouped in 3 scientific areas: (Area Group I) Biomolecular Structure and Function, (Area Group II) Gene Expression and Regulation, and (Area Group III) Neurobiology. In addition to the main scientific areas, the unique skills of the Center's faculty were marshaled to develop an AIDS subgroup. Major equipment purchases and the creation of central facilities further enhanced the activity within the Center. In this application, we will reorganize our porgram. One (1) criticism of our last application was that Area II was too large and seemingly disorganized. After much discussion, we propose to reorganize its members into 2 new research areas. Area II members will either remain in Area II under the new focus of cancer development (cell cycling and signal transduction), or become members of Area IV which will be our immunology group. We will no longer have An AIDS subgroup. We propose to continue to strengthen our current research Center through the hiring of research active faculty members. The major focus of this application is to hire 1 scientist for each area. We propose to hire 1 x-ray crystallographer (Area I), 1 scientist in the area of cancer, (cell cycling and signal transduction) (Area II), 1 neurobiologist (Area III) and 1 immunologist (Area IV). We request to replace the old FACS Sorter and to purchase a Confocal Microscope. This application also includes a request for funds to update or replace outdated equipment used in our core facilities and funds to support contracts for several core facility items.