Patient-oriented research in early life origins of CVD

描述(由申请人提供)： 不仅在成人生活中起作用的因素，而且从受孕开始，都会对终身心血管健康产生影响。动物和人体研究，包括我们自己的研究，现在正在为儿童肥胖和心血管风险的产前和围产期决定因素提供有趣的线索。但缺乏前瞻性数据，将其转化为预防性干预措施才刚刚开始。在K24竞争延续基金的支持下，吉尔曼博士和他的受训者将在未来五年专注于这一领域的研究，这不仅是该领域本身的关键时期，也是继续扩大他做出重大贡献和培养该领域下一代以患者为导向的研究人员的潜力的关键时期。这项建议的具体目的是(1)检查儿童肥胖和心血管危险因素的产前和围产期决定因素。这些分析将利用正在进行的NIH资助的项目Viva提供的基础设施，该项目是一项对孕妇及其子女进行的前瞻性队列研究。(2)为初级临床研究人员的培训和发展提供有利的专业环境，他们将在Viva项目和其他正在进行的以患者为导向的慢性病生命过程方法领域的研究项目中进行研究。主要焦点将放在(1)肥胖的产前和围产期起源、心血管风险、哮喘和认知；(2)青春期饮食和体力活动的决定因素；以及(3)预防幼儿肥胖的创新干预措施。

DESCRIPTION (provided by applicant): Factors operating not only in adult life, but also from conception, have impact on lifelong cardiovascular health. Animal and human studies, including our own, are now providing intriguing clues into the pre- and perinatal determinants of childhood obesity and cardiovascular risk. But prospective data are lacking, and translation into preventive interventions has only just begun. With the support from this K24 competing continuation grant, Dr. Gillman and his mentees will focus intensively on this area of research for the next five years, a critical period not only for the field itself, but also for continuing to expand his potential for significant contributions and for nurturing the next generation of patient-oriented researchers in this field. The specific aims of this proposal are (1) To examine pre- and perinatal determinants of childhood obesity and cardiovascular risk factors. These analyses will take advantage of the infrastructure provided by the ongoing NIH-funded Project Viva, a prospective cohort study of pregnant women and their children. (2) To provide a nourishing professional environment for the training and advancement of beginning clinical researchers, who will conduct studies within Project Viva and other ongoing patient-oriented research projects in the area of the life course approach to chronic disease. Major foci will be in the areas of (1) pre- and perinatal origins of obesity, cardiovascular risk, asthma, and cognition; (2) determinants of diet and physical activity in adolescence; and (3) innovative interventions to prevent obesity in young children.