Extramural Research Facility Construction Projects. Ros*

描述（由申请人提供）： 该NTH建筑申请要求2，401，705美元，用于翻新第四层的第三和四分之三（20，763净平方米）。在罗斯威尔公园癌症研究所（RPCI）的30岁的5层癌症细胞中心大楼（CCC）中，由肿瘤免疫治疗计划占用。 位于RPCI校园的CCC与新水牛生命科学综合体（2006年6月完工）的癌症遗传学和药理学以及分子生物学和生物物理学系相互联系。此外，CCC将连接到豪普特曼伍德沃德研究所（HWI）住房中心的结构生物学和晶体学（2005年3月入住）和布法罗大学生物信息学中心（2006年6月完成）。因此，位于CCC内拟议翻新空间内的组装免疫治疗计划将提供与RPCI其他计划进行更密切的科学和临床互动的绝佳机会，从而增强转化研究机会。 RPCI免疫学系内的拟议翻新将容纳八名同行评审资助的研究人员和一名正在招聘的额外高级教员，其共同研究重点旨在确定用于癌症患者选择性免疫疗法开发的免疫标记物。 这一要求是免疫学系和研究所总体战略计划的一个重要组成部分。将被安置在翻新空间的教职员工目前位于几个不同的建筑物与过时的实验室。因此，拟议的翻新不仅对加强正在进行的基础和转化研究至关重要，而且对教师的招聘和保留也至关重要。

DESCRIPTION (provided by applicant): This NTH construction application is requesting $2,401,705 to renovate the third and three-quarters of the fourth floor (20,763 net sq. ft) in the 30-year-old, 5-story Cancer Cell Center building (CCC) at Roswell Park Cancer Institute (RPCI) for occupancy by the Tumor Immunotherapy Program. The CCC located on RPCI's campus is interconnected with Cancer Genetics and Pharmacology in the new Buffalo Life Science Complex (June '06 completion) and the Departments of Molecular Biology and Biophysics. Also, the CCC will connect to the Hauptman Woodward Institute (HWI) housing the Center for Structural Biology and Crystallography (March '05 occupancy) and the University of Buffalo Center of Bioinformatics (June '06 completion). Thus, the assembled Immunotherapy Program located within the proposed renovated space within the CCC will provide an outstanding opportunity for closer scientific and clinical interactions with other programs at RPCI resulting in enhanced translational research opportunities. The proposed renovation within the Department of Immunology at RPCI will house eight peer-reviewed funded investigators and one additional senior faculty member under recruitment with a common research focus aimed at the identification of immunological markers for the development of selective immunotherapy for cancer patients. This request is a critical component of the overall strategic plan of the Immunology Department and the Institute. The faculty members to be housed in the renovated space are presently located in several different buildings with outdated laboratories. Thus, the proposed renovation is not only critical for enhancement of ongoing basic and translational research but for the recruitment and retention of faculty.