Cardiac Arrhythmias: Linking Structural Biology to Gene Defects

心律失常提供了对心脏的广泛的新的理解，提供了新的治疗方法和新的治疗方法。新的发现将在一系列紧密结合的讲座中公布，内容涉及结构和分子生物学、细胞生物学和生理学、治疗学和临床方法。研讨会将汇集一个独特的小组，他们在结构生物学、分子和系统生理学以及靶向发现和药物开发的工业方法方面具有专业知识。 新发现的蛋白质结构提供了对离子通道行为和调节的洞察。这项工作跨越了K+、Na+、Ca~(2+)、RyR和IP3R通道的正常和疾病相关基因突变的行为、结构和功能。此外，大分子复合体已经被识别和表征，并揭示了特定元件如何提供对心脏细胞信号的非凡局部控制。亚细胞组织依赖于细胞骨架组织，已被证明对正常细胞功能和疾病有重要贡献。新的分子和药理学治疗方法产生于这一认识。 这次会议将介绍与心脏节律有关的关键分子的新研究成果。 骚乱。心血管疾病是美国男性和女性的主要死亡原因。 这次会议将探索我们对心脏功能的理解，在最基本的分子水平上，并讨论新的分子治疗方法。

cardiac arrhythmias provide broad new understanding of the heart, providing novel remedies and new approaches for treatment. The new findings will be presented in a tightly integrated set of talks covering structural and molecular biology, cell biology and physiology and therapeutics and clinical approaches. The symposium will bring together a unique group with expertise in structural biology, molecular and systems physiology, and industrial approaches to target discovery and drug development. Newly identified protein structures provide insight into ion channel behavior and regulation. This work spans the behavior, structure and function of normal and disease-linked gene mutations of K+, Na+, Ca2+ , RyR and IP3R channels. In addition, macromolecular complexes have been identified and characterized and reveal how specific elements provide extraordinary local control of cardiac cellular signaling. The subcellular organization, dependent on cytoskeletal organization, has been shown to significantly contribute to the normal cell function and disease. New molecular and pharmacological approaches to treatment arise from this understanding. This meeting will present new research findings on key molecules involved in heart rhythm disturbances. Cardiovascular disease is the leading cause of death in both males and females in the United States. This meeting will explore our understanding of the functioning of the heart, at its most basic molecular level, and discuss new molecular treatments.