Hypoxia and Development, Physiology and Disease

描述（由申请人提供）：细胞在胚胎发育期间以及在多种疾病如中风、心脏病发作和癌症中会遇到缺氧或“缺氧”。开发影响细胞氧信号通路的药物应该能为这些常见疾病的患者提供更好的治疗。 目前对缺氧的研究集中在（1）细胞如何感知氧可用性的变化，（2）缺氧诱导因子如何调节正常发育和生理，以及（3）氧可用性如何影响疾病，如实体瘤，肺动脉高压和组织缺血。 该领域的主要问题包括理解缺氧后发生的多种细胞内变化。 这次会议的目的是汇集缺氧研究人员研究酵母，苍蝇，蠕虫，哺乳动物，发展，组织稳态，疾病和药物发现。

DESCRIPTION (provided by applicant): Oxygen deprivation, or "hypoxia", is encountered by cells during embryonic development, and in a variety of diseases such as stroke, heart attacks, and cancer. Developing drugs that impact cellular oxygen signaling pathways should yield better treatments for patients with these common illnesses. Research on hypoxia is currently focusing on (1) how cells sense changes in oxygen availability, (2) how hypoxia-inducible factors regulate normal development and physiology, and (3) how oxygen availability effects diseases such as solid tumors, pulmonary hypertension, and tissue ischemia. Major problems in the field include understanding multiple intracellular changes that occur upon oxygen deprivation. The goal of this meeting is to bring together hypoxia researchers studying yeast, fly, worm, mammals, development, tissue homeostasis, disease, and drug discovery.