FASEB SUMMER RESEARCH CONFERENCE: TRANSPORT ATPASES

描述（由申请人提供）： 这是FASEB夏季研究会议部分资金的申请，题为“运输ATP酶：基因组学，机制和疾病的相关性”。会议将于2005年7月16日至21日在佛蒙特州萨克顿河的佛蒙特学院举行。会议的目标是将150名参与者聚集在一个与世隔绝的环境中，进行为期五天的广泛的科学对话。会议计划包括两个专题讲座，九个会议，每个4讲座，3海报会议，和一个年轻的研究者论坛。将深入介绍的专题有：转运ATP酶的基因组调查，转运ATP酶与人类疾病的相关性，V-ATP酶的结构和机制，Ca-和Na. K-ATP酶的晶体结构和机制，阳离子泵与心脏功能和疾病的相关性，F-ATP酶/ATP合酶的晶体结构和机制，ABC转运蛋白的晶体结构和机制，ATP酶同工型的生理相关性，ABC转运蛋白在疾病中的不同作用，转运ATP酶作为纳米马达，以及P型阳离子泵的小蛋白调节剂。海报会议和青年研究者论坛将促进知名科学家和年轻科学家之间的交流;将强调妇女、少数民族和残疾人的招聘和积极参与。预计会议将在基础科学和医学科学方面具有重要意义。最近在晶体结构定义方面的快速进展促进了对机制的理解，并为计算机建模和药物开发开辟了途径。基因组调查揭示了越来越多的转运ATP酶及其与遗传疾病的联系。同样清楚的是，许多更常见的疾病状态的发病特征，如心力衰竭和耐药性，与转运ATP酶的表达或功能改变有关。这次会议，重点是运输ATP酶，但多学科的性质，因此非常明显地与国家卫生研究院的使命。

DESCRIPTION (provided by applicant): This is an application for partial funding for the FASEB Summer Research Conference entitled "Transport ATPases: Genomics, Mechanisms, and Relevance to Diseases". The conference will be held at Vermont Academy, Saxtons River, Vermont, from July 16-21, 2005. The goal of the meeting is to bring together -150 participants in a secluded environment for five days of extensive scientific dialog. The Conference Program encompasses two Special Lectures, nine Sessions with 4 lectures each, 3 Poster Sessions, and one Young Investigator Forum. Topics to be presented in depth will be: Genomic survey of transport ATPases, relevance of transport ATPases to human diseases, structure and mechanism of V-ATPases, crystal structures and mechanism of Ca- and Na.K-ATPase, relevance of cation pumps to cardiac function and disease, crystal structures and mechanism of F-ATPase/ATP synthase, crystal structures and mechanism of ABC transporters, physiological relevance of ATPase isoforms, diverse roles of ABC transporters in disease, transport ATPases as nanomotors, and small protein regulators of P-type cation pumps. The Poster Sessions and Young Investigator Forum will foster communication between established and younger scientists; recruitment and active participation of women, minorities, and persons with disabilities will be emphasized. It is expected that the conference will be highly-significant with regard to both basic and medical sciences. Rapid recent progress in definition of crystal structures has advanced understanding of mechanisms and opens up avenues for computer modeling and drug development. Genomic surveys reveal an increasing number of transport ATPases and their linkage to genetic diseases. It is also clear that pathogenetic features of many more common disease states, such as heart failure and drug resistance, are related to altered expression or function of transport ATPases. This conference, focussed on transport ATPases but multidisciplinary in nature, is therefore very clearly related to the mission of NIH.