Symposium on Structural Biology of DNA Repair

描述（由申请人提供）：本提案是为在华盛顿举行的美国化学学会全国会议上提交的为期一天的“DNA修复的结构生物学”专题讨论会获得财政支持的请求，2005年8月28日至9月1日。 不同的DNA修复途径已经进化，以保护基因组免受外源性和内源性损伤，因为正确的遗传信息的维持对所有生物体都至关重要。 突变是遗传性疾病和癌症的主要原因，也可能与衰老有关。 80%至90%的人类癌症最终是由于DNA损伤。 本次研讨会将集中讨论最近发现的Y家族DNA聚合酶在碱基切除修复、核苷酸切除修复、错配修复、同源重组和跨损伤合成等方面的进展。 本次研讨会选择的发言者将介绍上述不同修复途径的最新结果，重点是对不同修复途径的结构表征所取得的进展。 关于DNA修复的整个领域的概述将在会议开始时提出。 每个演讲者都在其专业领域享有国际声誉，研讨会的目标是将DNA修复领域的专家聚集在一起，以便他们能够教育科学界关于这些修复途径，从而吸引新的研究人员到该领域，并推动这一重要的研究领域向新的方向发展。主要的问题，如损伤识别和相互作用的多蛋白复合物对受损DNA的成功修复进行了探索，将是一个重要的因素，在新的化疗药物的发展。

DESCRIPTION (provided by applicant): This proposal is a request to obtain financial support for a one day symposium on "Structural Biology of DNA Repair" to be presented at the American Chemical Society National Meeting in Washington D.C., August 28th - September 01st, 2005. Different DNA repair pathways have evolved to protect the genome from exogenous and endogenous damage since the maintenance of the correct genetic information is crucial for all living organisms. Mutations are the primary cause of hereditary diseases, as well as cancer, and may also be involved in aging. 80 to 90% of all human cancers are ultimately due to DNA damage. This symposium will focus on the advances made in the areas of base excision repair, nucleotide excision repair, mismatch repair, homologous recombination and translesion synthesis by the recently discovered Y-family DNA polymerases. The speakers chosen for this symposium will present the most recent results obtained for the different repair pathways listed above with an emphasis on the advances made towards the structural characterization of the different repair pathways. An overview about the entire field of DNA repair will be presented at the beginning of the meeting. Each of the speakers have international reputations in their areas of expertise and the goal of the symposium will be to bring experts in the field of DNA repair together so that they will be able to educate the scientific community concerning these repair pathways and thereby attract new investigators to the field and to propel this important area of research in new directions. Major questions such as damage recognition and the interaction of multi-protein complexes towards the successful repair of damaged DNA have to be explored and will be an important factor in the development of new chemotherapeutic agents.