2005 Plant Metabolic Engineering Gordon Res. Conference

描述（由申请人提供）：后基因组时代为操纵植物化学提供了新的机会，这将影响全球食品供应的水平和营养含量，并导致新药和治疗激素的新生物来源。最近批准的新的戈登研究会议（GRC）植物代谢工程将提供一个环境，发展所需的多学科合作，以解开植物代谢网络的动态复杂性和推进植物代谢工程的基础和应用研究。会议将整合基因组学的最新进展，代谢物和基因表达分析。研究讨论将探讨生物合成途径如何与底物竞争和通道，生物合成酶的可塑性相互作用，并研究本地化，结构和组装的生物合成复合物在本地和非本地环境。会议将为植物转基因研究开发新的视角，关于转基因表达如何影响细胞代谢。将光谱方法与数学建模相结合，用于代谢分析和通量分析，将有助于合理的代谢工程策略的发展，并导致新工具的演变，以评估代谢物库的时间和亚细胞变化。会议还将重点介绍途径工程的新技术，包括使用异源系统，定向酶进化，转录因子工程和控制生物合成途径的分子/遗传技术的应用。第一次会议将于2005年7月10日至15日在新罕布什尔州蒂尔顿的蒂尔顿学校举行，此后每两年举行一次。演讲者和参与者将有大约130-150人来自美国和国外，来自各个职业层次，代表学术界，工业界，私营机构和联邦实验室。将作出协调一致的努力，使妇女、残疾人和代表性不足群体的科学家有适当的代表性。

DESCRIPTION (provided by applicant): The post-genomic era presents new opportunities for manipulating plant chemistry that will impact the level and nutritional content of the global food supply and lead to new biological sources of novel drugs and therapeutic hormones. The recently approved new Gordon Research Conference (GRC) on Plant Metabolic Engineering will provide a setting for developing multidisciplinary collaborations needed to unravel the dynamic complexity of plant metabolic networks and advance basic and applied research in plant metabolic engineering. The conference will integrate recent advances in genomics, with metabolite and gene expression analyses. Research discussions will explore how biosynthetic pathways interact with regard to substrate competition and channeling, plasticity of biosynthetic enzymes, and investigate the localization, structure, and assembly of biosynthetic complexes in native and nonnative environments. The conference will develop new perspectives for plant transgenic research with regard to how transgene expression may influence cellular metabolism. Incorporation of spectroscopic approaches for metabolic profiling and flux analysis combined with mathematical modeling will contribute to the development of rational metabolic engineering strategies and lead to the evolvement of new tools to assess temporal and subcellular changes in metabolite pools. The conference will also highlight new technologies for pathway engineering, including use of heterologous systems, directed enzyme evolution, engineering of transcription factors and application of molecular/genetic techniques for controlling biosynthetic pathways. The first conference will take place July 10-15, 2005 at the Tilton School, Tilton, New Hampshire and every two years thereafter. Speakers and participants will number approximately 130-150 from the US and abroad, at all career levels, and represent institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will be made for appropriate representation by women, persons with disabilities, and scientists from underrepresented groups.