Proprotein Processing, Trafficking and Secretion Gordon Conference

描述（由申请人提供）：第五届激素和神经肽生物合成戈登研究会议将于2002年7月21日至26日在新伦敦，新罕布什尔州举行。这次会议已经确立了自己作为一个重要的论坛，讨论快速移动领域的加工酶和其他蛋白酶参与内分泌和中枢神经系统的稳态和疾病。这个跨学科会议的主要重点是生物化学和细胞生物学的生物活性肽合成内分泌和神经元细胞，其范围包括分子生物学，生物化学，生物物理学和遗传学的方法来了解肽的功能。在产生生物活性肽的细胞中发挥作用的多种相互作用负责生理学和疾病病因学中的许多调节过程，包括糖尿病，癌症，阿尔茨海默氏症和药物成瘾。为了解决这些问题，受邀演讲者将从领先的资深科学家到年轻科学家，提供最新的令人兴奋的数据，并为有希望的后期发展预留空间。会议将涵盖激素和神经肽合成和加工的遗传学和生理学，前蛋白加工酶的生物化学和结构分析，加工酶在人类生理学和疾病中的作用，蛋白质分选和定位的结构和调节，高尔基体结构和功能，刺激反应区室的形成，靶向分泌颗粒和突触囊泡，胞吐作用的调节，和肽多样性的新方法。 由于其跨学科的重点是内分泌和神经元细胞生物化学及其人体生理学和疾病的整合，这次会议是潜在的兴趣，使命的几个研究所，包括NIDDK，NINDS和NIDA。分子和细胞的进展，在几个方面的蛋白质前体加工，贩运和分泌相关的内分泌和神经疾病的理解将是会议的中心特征，并在蛋白质前体加工，贩运和分泌功能障碍将得到彻底解决。正常生理和人类疾病所需的蛋白酶系统的整合将与我们对糖尿病，癌症，阿尔茨海默氏症和药物成瘾的分子基础的理解有关。

DESCRIPTION (provided by applicant):The fifth Hormonal and Neural Peptide Biosynthesis Gordon Research Conference will be held from July 21-26, 2002 in New London, NH. This conference has established itself as an important forum for discussing the rapidly moving field of processing enzymes and other proteases involved in endocrine and CNS homeostasis and disease. The principal focus of this interdisciplinary meeting is on the biochemistry and cell biology of bioactive peptide synthesis in endocrine and neuronal cells, and its scope incorporates molecular biological, biochemical, biophysical, and genetic approaches to understanding peptide function. The multiple interactions that come into play in cells that produce bioactive peptides are responsible for many regulatory processes in physiology and the etiology of diseases, including diabetes, cancer, Alzheimer's, and drug addiction. To address these issues, invited speakers will range from leading senior scientists to junior scientists with recent, exciting data, with spaces reserved for promising late developments. The conference will cover the genetics and physiology of hormonal and neural peptide synthesis and processing, the biochemistry and structural analysis of proprotein processing enzymes, the role of processing enzymes in human physiology and disease, structure and regulation in protein sorting and localization, Golgi structure and function, formation of stimulus-responsive compartments, targeting to secretory granules and synaptic vesicles, regulation of exocytosis, and new approaches to peptide diversity. Because of its interdisciplinary emphasis on endocrine and neuronal cell biochemistry and its integration of human physiology and disease, this conference is of potential interest to the mission of several institutes, including NIDDK, NINDS and NIDA. Molecular and cellular advances in the understanding of several aspects of proprotein processing, trafficking, and secretion relevant to endocrine and neural diseases will be a central feature of the conference, and dysfunction in proprotein processing, trafficking and secretion will be thoroughly addressed. The integration of protease systems that are required both for normal physiology and human disease will be relevant to our understanding of the molecular bases of diabetes, cancer, Alzheimer's and drug addiction.