AMPK: Impact on Metabolism and Disease

描述(由申请人提供)： AMPK领域正在快速发展，它在人类疾病的发病机制和治疗中的作用，特别是在糖尿病、肥胖症和心血管疾病领域的作用，已经成为生物医学界的主要兴趣。本申请的目的是请求NIH支持将于2006年8月12-17日在科罗拉多州斯诺马斯举行的关于AMP激酶：对哺乳动物新陈代谢和疾病的影响的FASEB会议。关于这一主题的国际会议应该有助于发展富有成效的合作，这将对理解AMPK在细胞新陈代谢中的作用产生重大影响。这次会议是在2000年以来成功举办的一系列三次国际会议的基础上发展而来的，这是认识到AMPK在糖尿病和肥胖症等老年性疾病中的重要性以及我们对AMPK在心脏病和癌症中的重要性日益加深的直接结果。会议的目标是促进和推进AMPK领域的研究，特别强调了解导致肥胖、糖尿病和心脏病的机制。我们得到了来自美国、加拿大、欧洲、澳大利亚和日本的几乎所有AMPK领域主要科学家的参与承诺。这将包括青年、女性和少数族裔科学家参与这些研究领域。主要主题包括：1)AMPK、AMPK激酶及其调控，2)AMPK与其他信号系统的相互作用，3)AMPK的激素调节，4)AMPK与细胞生长/存活和癌症，5)AMPK、脂毒性和代谢综合征，6)AMPK与心血管疾病，7)AMPK与运动控制 8)AMPK作为药理靶点。

DESCRIPTION (provided by applicant): The AMPK field is moving forward at a rapid pace and its role in the pathogenesis and treatment of human diseases, especially in the areas of diabetes, obesity, and cardiovascular disease has become a major interest for the biomedical community. The purpose of this application is to request NIH support of the 2006 FASEB conference on AMP Kinase: Impact on Mammalian Metabolism and Disease to be held in Snowmass, Colorado on August 12-17, 2006. An international meeting on this topic should facilitate the development of productive collaborations that will have a substantial impact on understanding the role of AMPK in cellular metabolism. The conference has evolved from a series of three successful international meetings held since 2000, a direct result of the realization of AMPK's importance in age onset diseases such as diabetes and obesity, as well as our growing understanding of the importance of AMPK in heart disease and cancer. The goals of the conference are to facilitate and advance research in the AMPK field, with particular emphasis on understanding the mechanisms leading to obesity, diabetes and heart disease. We have commitments for participation from almost all of the major scientists in the AMPK field from the US, Canada, Europe, Australia and Japan. This will include involvement of young, female and minority scientists in these research areas. Major themes will be 1) AMPK, AMPK kinases and their regulation, 2) interaction of AMPK with other signaling systems, 3) hormonal regulation of AMPK, 4) AMPK and cell growth/survival and cancer, 5) AMPK, lipotoxicity and the metabolic syndrome, 6) AMPK and cardiovascular disease, 7) AMPK in the control of exercise metabolism, and 8) AMPK as a pharmacological target.