Metal Carcinogenesis: New Concepts

描述（由申请人提供）：本提案要求在2006年9月10日至14日在加州旧金山举行的美国化学会年会上，为为期半天的“金属致癌：新概念”研讨会提供资金支持。有几种金属早就被认为是人类致癌物；然而，它们的致癌性机制仍然难以捉摸，在大多数情况下，不涉及直接的DNA损伤或显著的诱变诱导。由于几种活性金属配合物的鉴定，细胞代谢在最终遗传毒性物种形成中的重要性的确立以及金属共同致癌潜力的发现，金属致癌领域最近取得了重大进展。这三个新兴领域是本次研讨会的主要议题。演讲者的选择是基于他们在制定金属致癌新概念方面的国际声誉和科学领导地位。本次研讨会的主要目标是向广泛的科学界介绍这些新概念，并确定研究需求和未来方向，从而在金属致癌和共致癌领域取得进一步进展。

DESCRIPTION (provided by applicant): This proposal requests financial support for a half-day symposium on "Metal Carcinogenesis: New Concepts" to be held during the American Chemical Society Annual Meeting in San Francisco, CA, on September 10-14, 2006. Several metals have long been known as human carcinogens; however, the mechanisms of their carcinogenicity remained elusive and in most cases, did not involve direct DNA damage or significant induction of mutagenesis. The field of metal carcinogenesis has recently experienced major advances due to identification of several reactive metal complexes, establishment of the importance of cellular metabolism in the formation of ultimate genotoxic species and discovery of co-carcinogenic potential of metals. These three emerging areas are the main topics of the symposium. The speakers were chosen based on their international reputation and scientific leadership in the formulation of the novel concepts in metal carcinogenesis. The main goal of this symposium is to present these new concepts to a broad scientific community and to identify research needs and future directions that would lead to further advances in the field of metal carcinogenesis and co-carcinogenesis.