2006 Thiol-based Redox Regulation and Signaling Gordon Research Conference

描述（由申请人提供）：在过去的十年中，氧化还原信号领域首先出现，然后爆炸。 细胞生命的几乎每一个方面都与氧化还原过程有关。氧化还原控制的核心是利用硫醇进行氧化还原化学的系统。 含巯基蛋白质是细胞中的主要抗氧化剂，并且各种磷酸酶、激酶和转录因子中的巯基的可逆氧化将基于巯基的氧化还原生物学与基于磷酸化的信号传导、凋亡、细胞周期调节和其他过程和途径联系起来。 硫醇基氧化还原稳态的失调对癌症、心血管疾病的发展具有重要意义，并且是调节衰老的因素之一。 尽管基于巯基的氧化还原反应和细胞过程之间的相互联系越来越多，并且在疾病中的作用的证据越来越多，但没有正式的会议存在，将这一领域的研究人员联系起来，这一领域正在迅速获得动力。 我们相信，一个专题会议将汇集研究硫醇基氧化还原系统的研究人员，以促进新数据的共享和具有重叠研究兴趣的同事之间的互动。 在全球研究理事会的保护伞下组织的会议将有助于招聘该领域的顶尖研究人员，并为会议的成功提供必要的组织支持。 一次全球风险理事会会议将填补一个独特的空白，并有助于突出一个公认日益重要的领域。 该计划将包括该领域现有和新兴领导人以及初级和高级调查人员的多样化组合。

DESCRIPTION (provided by applicant): Over the past ten years, the field of redox signaling first emerged and then exploded. Almost every aspect of cellular life has been linked to redox processes. Central to redox control are systems that utilize thiols to perform redox chemistry. Thiol-containing proteins are major antioxidants in cells and reversible oxidation of thiols in various phosphatases, kinases and transcription factors has linked thiol-based redox biology to phosphorylation-based signalling, apoptosis, cell cycle regulation and other processes and pathways. Dysregulation of thiol-based redox homeostasis has major implications for the development of cancer, cardiovascular diseases, and is one of the factors that regulates aging. Despite the increasing interconnections between thiol-based redox reactions and cellular processes and evidence for the role in disease, no formal conference exists that links researchers in this field that is rapidly gaining momentum. We believe that a thematic conference will bring together researchers working on thiol-based redox systems to promote sharing of new data and interactions between colleagues with overlapping research interests. A conference organized under the GRC umbrella will facilitate recruitment of the top researchers in the field and provide the organizational support necessary for a successful conference. A GRC conference would fill a unique niche and serve to highlight an area that is recognized to be of growing importance. A diverse mix of established and emerging leaders in the field, and of junior and senior investigators will be included in the program.