The role of commensal bacteria in the skins response to ultraviolet radiation

我们的皮肤是由各种各样的细菌和其他微生物，有助于我们的生理健康。这被称为皮肤微生物组。在每天影响皮肤的众多环境因素中，来自阳光的紫外线辐射（UVR）可以说是最重要的。与其他人体微生物相比，皮肤的细菌是独特的，因为它们经常暴露在紫外线下。细菌对紫外线辐射有反应，这一点已经得到了很好的证实，因为许多研究都将紫外线辐射作为一种灭菌方法。然而，皮肤微生物群对UVR的反应尚未进行任何详细研究。特别是，皮肤上的细菌是否可以改变皮肤细胞（角质形成细胞）对UVR的反应尚不清楚。我们有初步证据表明，皮肤微生物组的成员可以改变角质形成细胞对UVR的反应。我们已经表明，特定的细菌可以促进UVR暴露的角质形成细胞的凋亡。其他细菌可以促进UVR暴露后角质形成细胞的存活。在这个项目中，我们将更详细地研究这些反应。我们的目标是：1）鉴定细菌中促进暴露于UVR后角质形成细胞凋亡或存活的因子2）使用微阵列，开始鉴定细菌组分修饰的信号通路

Our skin is populated by an assortment of bacteria and other microorganisms that contribute to our physiological health. This is known as the skin microbiome. Among the numerous environmental factors that impact upon skin on a daily basis, ultraviolet radiation (UVR) from sunlight is arguably the most important. In contrast to other human microbiomes, the commensal bacteria of the skin are unique in that they are regularly exposed to UVR. That bacteria are responsive to UVR is well established given numerous studies looking at the use of UVR as a method of sterilisation. However, the response of the skin microbiota to UVR has not been studied in any detail. In particular, whether the bacteria on skin can alter the response of skin cells (keratinocytes) to UVR is unknown.We have preliminary evidence that members of the skin microbiome can modify the response of keratinocytes to UVR. We have shown that particular bacteria can promote apoptosis of UVR exposed keratinocytes. Other bacteria can promote the survival of keratinocytes following UVR exposure. In this project, we will study these responses in more detail. We will aim to:1) Identify the factors in bacteria that promote apoptosis or survival of keratinocytes following exposure to UVR2) Using microarray, begin to identify the signalling pathways modified by bacterial components